专利检索 ap:("CIY OF HOPE") AND inv:"Defu ZENG" 第 1 页

1.

发明公开
PREVENTION AND TREATMENT OF STEROID-RESISTANT OR GUT GRAFT-VERSUS-HOST DISEASE (GVHD) 审中-公开

公开(公告)号：US20240083998A1

公开(公告)日：2024-03-14

申请号：US18270706

申请日：2022-01-03

申请人： CIY OF HOPE

发明人： Defu ZENG , Qingxiao SONG , Arthur D. RIGGS

IPC分类号： C07K16/24 , A61K35/15 , A61K35/17 , A61P1/00 , A61P37/06 , C07K16/30 , C07K16/40

CPC分类号： C07K16/248 , A61K35/15 , A61K35/17 , A61P1/00 , A61P37/06 , C07K16/3007 , C07K16/40 , A61K2039/505

摘要： Disclosed is a method of preventing or treating acute GVHD (aGVHD) such as gut aGVHD, steroid-resistant aGVHD, and steroid-resistant gut aGVHD in a subject receiving a hematopoietic cell transplantation (HCT) or autoimmune colitis by administering to the subject an effective amount of an anti-IL-22 antibody, an anti-IL-6 antibody, donor-type CX3CR1hi MNPs, donor-type NK cells, a ceacam-1 antagonist, an anti-Gr-1 antibody, or a combination thereof.