公开(公告)号：US09856213B2

公开(公告)日：2018-01-02

申请号：US14965515

申请日：2015-12-10

申请人： CHINOIN ZRT

发明人： Gábor Havasi ,  Tibor Kiss ,  Irén Hortobágyi ,  Zsuzsanna Kardos ,  István Lászlófi ,  Zoltán Bischof ,  Ádám Bódis

IPC分类号： C07C405/00 ,  C07D207/46 ,  C07D209/48 ,  C07D233/60 ,  C07D307/935 ,  C07D209/50

CPC分类号： C07C405/0041 ,  C07B2200/13 ,  C07C405/00 ,  C07C2601/08 ,  C07D207/46 ,  C07D209/48 ,  C07D209/50 ,  C07D233/60 ,  C07D307/935

摘要： The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl-group, optionally substituted with —ONO2 group, or an aralkyl- or aryl-group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl-group, Y represents (CH2)n group or O atom or S atom, and where n=0-3.

公开(公告)号：US09573892B2

公开(公告)日：2017-02-21

申请号：US14965489

申请日：2015-12-10

申请人： CHINOIN ZRT

发明人： Gábor Havasi ,  Tibor Kiss ,  Irén Hortobágyi ,  Zsuzsanna Kardos ,  István Lászlófi ,  Zoltán Bischof ,  Ádám Bódis

IPC分类号： C07C405/00 ,  C07D207/46 ,  C07D209/48 ,  C07D209/50 ,  C07D233/60 ,  C07D307/935

CPC分类号： C07C405/0041 ,  C07B2200/13 ,  C07C405/00 ,  C07C2601/08 ,  C07D207/46 ,  C07D209/48 ,  C07D209/50 ,  C07D233/60 ,  C07D307/935

摘要： The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula, the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl-group, optionally substituted with —ONO2 group, or an aralkyl- or aryl-group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl-group, Y represents (CH2)n group or O atom or S atom, and where n=0-3.

摘要翻译： 本发明的主题是制备通式I的前列腺素酰胺的方法，其中在该式中，用虚线标记的键可以是单键或双键，在5,6位的双重界限的情况下， 13,14可以是顺式或反向取代，Q代表羟基，Z代表羟基或氧代基，R1和R2独立地表示氢原子或直链或支链C1-10烷基或 任选被-ONO 2基团取代的芳烷基，或含有杂原子的芳烷基 - 或芳基，R 3表示直链或支链，饱和或不饱和的C 4-6烃基或C 4-10烷基环烷基 - 或环烷基 - 基团或任选具有烷基或卤素原子取代的苯基，C 7-10烷基芳基或杂芳基，Y表示（CH 2）n基团或O原子或S原子，并且其中n = 0-3。