公开(公告)号：US3911138A

公开(公告)日：1975-10-07

申请号：US33545473

申请日：1973-02-26

申请人： CHILDREN S HOSPITAL INC OF CIN

发明人： CLARK JR LELAND C

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/025 ,  B01F17/42

CPC分类号： A61K9/0026 ,  A61K31/025 ,  Y10T436/102499 ,  Y10T436/105831

摘要： Perfluorocyclocarbons and emulsions containing emulsified particles of these perfluorocarbons are useful is supporting life as intravascular oxygen and carbon dioxide transport agents. Stable emulsions of perfluorocarbocyclic derivatives are prepared for use as artificial bloods and perfusates for organs. Intravenously infused emulsions containing perfluorocyclocarbons such as perfluoro(methylcyclohexane), perfluoro(1,3dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), and the like, serve as intravascular oxygen and carbon dioxide transport agents. Fluorocarbon liquids are also useful as an external respiration media for transporting oxygen-carbon dioxide necessary to support intravascular respiration. Perfluorocyclocarbons have been found after intravenous emulsion infusion as artificial bloods to collect in the reticuloendothelial system (RES) of the amimal body. However, it has also been found that perfluorocyclocarbon compounds leave the RES of the animal body and certain of these compounds, e.g., perfluoro(decahydronaphthalene), leave the RES at a much faster rate than others. Furthermore, after the intravenously infused perfluorocyclocarbon emulsions function as artificial bloods, the perfluorocyclocarbons have the capability of leaving the animal body through the tissue, e.g., the lungs and skin.

摘要翻译： 包含这些全氟化碳的乳化颗粒的全氟环己烷和乳液可用作血管内氧和二氧化碳转运剂的寿命。 制备全氟碳环衍生物的稳定乳液，用作器官的人造血液和灌注液。 包含全氟（甲基环己烷），全氟（1,3-二甲基环己烷），全氟（十氢萘），全氟（十氢-1-甲基萘），全氟（十氢二甲基萘）等全氟环己烷的静脉注入乳液，作为血管内氧和碳 二氧化物运输代理商。 氟碳液体也可用作输送支持血管内呼吸所必需的氧 - 二氧化碳的外部呼吸介质。 在静脉注射乳液后，已经发现全氟化碳在人体血液中被收集到哺乳动物的网状内皮系统（RES）中。 然而，也已经发现，全氟环烷化合物离开动物体的RES，并且这些化合物中的某些化合物，例如全氟（十氢萘）以比其它化合物更快的速率离开RES。 此外，在静脉内输注的全氟环烷酸乳剂作为人造血液之后，全氟环烷烃具有将动物体离开组织例如肺和皮肤的能力。