公开(公告)号：US20240358827A1

公开(公告)日：2024-10-31

申请号：US18638633

申请日：2024-04-17

申请人： CELLTRION INC.

发明人： Joon Won LEE ,  Yeon Kyeong SHIN ,  Hye Young KANG ,  Kwang Woo KIM ,  So Young KIM ,  Su Jung KIM ,  Jun Seok OH ,  Won Yong HAN

IPC分类号： A61K39/395 ,  A61K9/08 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24

CPC分类号： A61K39/39591 ,  A61K9/08 ,  A61K39/3955 ,  A61K47/12 ,  A61K47/183 ,  C07K16/00 ,  A61K47/26 ,  C07K14/525 ,  C07K16/241

摘要： Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.

公开(公告)号：US20190248871A1

公开(公告)日：2019-08-15

申请号：US16345453

申请日：2017-10-26

申请人： CELLTRION INC.

发明人： Joon Won LEE ,  Won Yong HAN ,  Su Jung KIM ,  Jun Seok OH ,  So Young KIM ,  Kwang Woo KIM ,  Yeon Kyeong SHIN

IPC分类号： C07K14/705 ,  A61K39/395 ,  A61K9/08 ,  A61K47/12 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

CPC分类号： C07K14/70578 ,  A61K9/00 ,  A61K9/08 ,  A61K38/16 ,  A61K39/39591 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C07K2319/30

摘要： Disclosed is a stable pharmaceutical formulation, comprising a fusion protein in which the extracellular ligand-binding domain of a human p75 tumor necrosis factor receptor is fused to the Fc domain of human IgG and a succinate buffering agent, without comprising a stabilizer. The stable pharmaceutical formulation enables the long-term storage of the TNFR-Fc fusion protein formulation and can exhibit superior storage stability without the need for demanding storage conditions, and is a simple formulation because no stabilizer is comprised therein and is thus more economical than other stabilizer-comprising formulations.

公开(公告)号：US20210205454A1

公开(公告)日：2021-07-08

申请号：US17202982

申请日：2021-03-16

申请人： CELLTRION INC.

发明人： Joon Won LEE ,  Yeon Kyeong SHIN ,  Hye Young KANG ,  Kwang Woo KIM ,  So Young KIM ,  Su Jung KIM ,  Jun Seok OH ,  Won Yong HAN

IPC分类号： A61K39/395 ,  A61K9/08 ,  A61K47/12 ,  A61K47/18

摘要： Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.