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公开(公告)号：US20110105401A1
公开(公告)日：2011-05-05
申请号：US12968532
申请日：2010-12-15
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US07888462B2
公开(公告)日：2011-02-15
申请号：US12018080
申请日：2008-01-22
IPC分类号： C07K14/00
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US20090074876A1
公开(公告)日：2009-03-19
申请号：US12018080
申请日：2008-01-22
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US08426558B2
公开(公告)日：2013-04-23
申请号：US12968532
申请日：2010-12-15
IPC分类号： C07K14/00
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US07638486B2
公开(公告)日：2009-12-29
申请号：US11457091
申请日：2006-07-12
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two proteins is administered to enhance biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译： 公开了促进生物过程以形成或再生新的硬组织如骨骼，软骨和/或牙科组织的制剂和方法。 施用包含两种蛋白质的制剂以增强硬组织生长和分化因子的生物活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，所述细胞内酶和信号分子在增殖，分化，成熟中起重要作用 ，和/或使硬组织形成细胞矿化。
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公开(公告)号：US07622438B1
公开(公告)日：2009-11-24
申请号：US11457088
申请日：2006-07-12
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译： 公开了促进生物过程以形成或再生新的硬组织如骨骼，软骨和/或牙科组织的制剂和方法。 该制剂增强了硬组织生长和分化因子的生物活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，其对于增殖，分化，成熟和/或矿化起重要作用 硬组织细胞。
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公开(公告)号：US20080145412A1
公开(公告)日：2008-06-19
申请号：US11735727
申请日：2007-04-16
摘要： The present invention is a method for promoting angiogenesis by administering a formulation comprising an effective amount of a peptidic compound, e.g., a peptide having the sequence TDLQERGDNDISPFSGDGQPFKD (SEQ ID NO: 30), which enhances angiogenesis through the induction of pro-angiogenic factors such as FGF2, TGFβ and fibronectin. Formulations may be administered by catheter to treat or prevent diseases and conditions which involve angiogenesis by administering an effective amount of the peptidic compound alone or in combination with one or more additional therapeutic agents.
摘要翻译： 本发明是通过施用包含有效量的肽化合物（例如具有序列TDLQERGDNDISPFSGDGQPFKD（SEQ ID NO：30）的肽）的制剂来促进血管生成的方法，其通过诱导促血管生成因子如 如FGF2，TGFbeta和纤连蛋白。 制剂可以通过导管施用以通过单独施用有效量的肽化合物或与一种或多种另外的治疗剂组合来治疗或预防涉及血管生成的疾病和病症。
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公开(公告)号：US20080096798A1
公开(公告)日：2008-04-24
申请号：US11457091
申请日：2006-07-12
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two proteins is administered to enhance biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译： 公开了促进生物过程以形成或再生新的硬组织如骨骼，软骨和/或牙科组织的制剂和方法。 施用包含两种蛋白质的制剂以增强硬组织生长和分化因子的生物活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，所述细胞内酶和信号分子在增殖，分化，成熟中起重要作用 ，和/或使硬组织形成细胞矿化。
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