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公开(公告)号：US20190330614A1
公开(公告)日：2019-10-31
申请号：US16473215
申请日：2016-12-30
发明人： Howard CHOU , Ling CHEN , Wenqiang LU , Xiucai LIU
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
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公开(公告)号：US20200231999A1
公开(公告)日：2020-07-23
申请号：US16473149
申请日：2016-12-30
发明人： Howard CHOU , Wenqiang LU , Ling CHEN , Xiucai LIU
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US20210054423A1
公开(公告)日：2021-02-25
申请号：US16961106
申请日：2018-01-09
发明人： Howard CHOU , Ling CHEN , Yunfeng LEI , Xiucai LIU
摘要： The invention provides microorganisms genetically modified to overexpress biofilm dispersal related polypeptides to enhance the production of lysine and lysine derivatives by the microorganism, method of generating such microorganism, and methods of producing lysine and lysine derivatives using the genetically modified microorganisms.
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公开(公告)号：US20210164003A1
公开(公告)日：2021-06-03
申请号：US16768336
申请日：2017-11-29
发明人： Howard CHOU , Ling CHEN , Xiucai LIU
摘要： Provided microorganisms genetically modified to overexpress an imine/enamine deaminase to enhance the production of lysine and lysine derivatives by the microorganism. Also provided a method of generating such microorganism, and methods of producing lysine and lysine derivatives using the genetically modified microorganisms.
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