公开(公告)号：US09919996B2

公开(公告)日：2018-03-20

申请号：US15406900

申请日：2017-01-16

Applicant: CATHAY R&D CENTER CO., LTD. ,  CATHAY INDUSTRIAL BIOTECH LTD.

Inventor： Xiucai Liu ,  Charlie Liu ,  Bingbing Qin ,  Naiqiang Li ,  XiaoMing Li

IPC: C07C209/84 ,  C07C209/86

CPC classification number: C07C209/84 ,  C07C209/86 ,  C07C211/09

Abstract: The invention relates to a method for preparing cadaverine comprising: (1) obtaining an aqueous cadaverine salt composition from a fermentation system; (2) adjusting the pH of the aqueous cadaverine salt composition to a pH of at least about 12 by adding an inorganic base composition to provide a first composition comprising an aqueous cadaverine composition having a pH of at least about 12 and a solid composition comprising one or more alkali metal sulfates; (3) subjecting the first composition to solid-liquid separation without organic solvent extraction to provide the aqueous cadaverine composition and the solid composition; (4) distilling or evaporating the aqueous cadaverine composition of step (3) without organic solvent extraction to provide purified cadaverine; (5) preparing a saturated solution of the alkali metal sulfate(s) from the solid composition of step (3) at a temperature of about 35-40° C., mixing the saturated solution with NH4HCO3, and subjecting the mixture to solid-liquid separation to provide Solution (I) and Solid (I); (6) adjusting the temperature of Solution (I) to about 60-80° C., and obtaining Solution (II) and Solid (II) after solid-liquid separation; (7) concentrating Solution (II) and obtaining Solution (III) and Solid (III) after solid-liquid separation; and (8) adding Solid (III) back to the fermentation system of step (1); wherein steps (1) to (8) are optionally repeated one or more times.

公开(公告)号：US09896409B2

公开(公告)日：2018-02-20

申请号：US15418071

申请日：2017-01-27

Applicant: CATHAY R&D CENTER CO., LTD. ,  CATHAY INDUSTRIAL BIOTECH LTD.

Inventor： Xiucai Liu ,  Charlie Liu ,  Bingbing Qin ,  Naiqiang Li ,  XiaoMing Li

IPC: C07C209/84

CPC classification number: C07C209/84 ,  C07C211/09

Abstract: One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising: a) distilling or evaporating the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed to produce purified cadaverine, wherein the evaporation or distillation is done at a heating temperature of about 80° C. to about 180° C. and under a pressure of 1 atm or lower, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least about 185° C. (1 atm); and b) recovering the one or more HBP solvents.