公开(公告)号：US20210198256A1

公开(公告)日：2021-07-01

申请号：US17192634

申请日：2021-03-04

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap ,  Rhamy Zeid

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D417/14

摘要： Compounds that degrade BRD9 or MTH1 via the ubiquitin proteasome pathway in a subject in need thereof for therapeutic applications are provided. The compounds provided have an E3 Ubiquitin Ligase targeting moiety (Degron) that is linked to a Targeting Ligand for BRD9 or MTH1.

公开(公告)号：US12049464B2

公开(公告)日：2024-07-30

申请号：US17901775

申请日：2022-09-01

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D401/14

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D401/14

摘要： BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

公开(公告)号：US20230060334A1

公开(公告)日：2023-03-02

申请号：US17901775

申请日：2022-09-01

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D401/14

摘要： BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

公开(公告)号：US20240245677A1

公开(公告)日：2024-07-25

申请号：US18600097

申请日：2024-03-08

申请人： C4 THERAPEUTICS, INC.

发明人： Katrina L. Jackson ,  Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap ,  Minsheng He ,  Robert T. Yu ,  Matthew J. Schnaderbeck ,  Kathleen Neville ,  Siyi Jiang ,  Meiqi Li ,  Qianwei Liu ,  Manjie Zheng ,  Jia Li ,  Liwei Zhang

IPC分类号： A61K31/496 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61P35/00

摘要： Selected BRD9 protein degradation compounds and morphic forms thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

公开(公告)号：US20240051953A1

公开(公告)日：2024-02-15

申请号：US17965569

申请日：2022-10-13

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap

IPC分类号： C07D471/04 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D401/14

摘要： BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

公开(公告)号：US11691972B2

公开(公告)日：2023-07-04

申请号：US17541035

申请日：2021-12-02

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakim ,  Jeremy L. Yap

IPC分类号： C07D471/04 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D401/14

摘要： A BRD9 protein degrading compound of structure




or a pharmaceutically acceptable salt thereof is provided for the treatment of a disorder mediated by BRD9, including but not limited to abnormal cellular proliferation including cancer.

公开(公告)号：US20220098194A1

公开(公告)日：2022-03-31

申请号：US17541035

申请日：2021-12-02

申请人： C4 Therapeutics, Inc.

发明人： Christopher G. Nasveschuk ,  Rhamy Zeid ,  Ning Yin ,  Katrina L. Jackson ,  Gesine Kerstin Veits ,  Moses Moustakin ,  Jeremy L. Yap

IPC分类号： C07D471/04 ,  C07D401/14 ,  A61P35/00

摘要： BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.