公开(公告)号：US20210379210A1

公开(公告)日：2021-12-09

申请号：US17285194

申请日：2019-10-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  James R. Corte ,  David J. Donnelly ,  Joonyoung Kim ,  Jun Shi ,  Shiwei Tao ,  Tritin Tran

IPC: A61K51/04 ,  C07D401/04

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I) or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.

公开(公告)号：US20250057995A1

公开(公告)日：2025-02-20

申请号：US18732745

申请日：2024-06-04

Applicant: Bristol-Myers Squibb Company

Inventor： Peter Tai Wah Cheng ,  James R. Corte ,  David J. Donnelly ,  Joonyoung Kim ,  Jun Shi ,  Shiwei Tao ,  Tritin Tran

IPC: A61K51/04 ,  C07D401/04

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I): or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.

公开(公告)号：US09987381B2

公开(公告)日：2018-06-05

申请号：US15032486

申请日：2014-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YALE UNIVERSITY

Inventor： Thomas Jon Seiders ,  David J. Donnelly ,  Samuel J. Bonacorsi, Jr. ,  Kai Cao ,  Tritin Tran ,  Adrienne Pena ,  Joonyoung Kim ,  Richard E. Carson ,  Nabeel Nabulsi ,  Jean-Dominique Gallezot ,  Yiyun Huang ,  Jeffrey Roger Roppe

IPC: A61K51/04 ,  C07D261/14 ,  C07B59/00 ,  A61B6/00

CPC classification number: A61K51/0453 ,  A61B6/481 ,  C07B59/002 ,  C07B2200/05 ,  C07D261/14

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.

公开(公告)号：US20160256577A1

公开(公告)日：2016-09-08

申请号：US15032486

申请日：2014-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YALE UNIVERSITY

Inventor： Thomas Jon Seiders ,  David J. Donnelly ,  Samuel J. Bonacorsi, JR. ,  Kai Cao ,  Tritin Tran ,  Adrienne Pena ,  Joonyoung Kim ,  Richard E. Carson ,  Nabel Nabulsi ,  Jean-Dominique Gallezot ,  Yiyun Huang ,  Jeffrey Roger Roppe

IPC: A61K51/04 ,  A61B6/00 ,  C07D261/14

CPC classification number: A61K51/0453 ,  A61B6/481 ,  C07B59/002 ,  C07B2200/05 ,  C07D261/14

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.

Abstract translation: 本发明涉及放射性标记的LPA1受体拮抗剂或其药学上可接受的盐，其可用于哺乳动物中LPA1受体的定量成像。