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公开(公告)号：US20220144929A1
公开(公告)日：2022-05-12
申请号：US17583245
申请日：2022-01-25
发明人： Leo THOMAS , Rachel Rebecca BARRETT , Kristin Laura BOVAT , Rajkumar GANESAN , Priyanka GUPTA , Fei HAN , Dongmei LIU , Juergen PRESTLE , Sanjaya SINGH , Sathyadevi VENKATARAMANI , Helen HAIXIA WU , Nina ZIPPEL
摘要： The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.
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公开(公告)号：US20220119536A1
公开(公告)日：2022-04-21
申请号：US17505763
申请日：2021-10-20
发明人： Peter Michael BENZ , Remko Alexander BAKKER , Holger FUCHS , Fei HAN , Sandeep KUMAR , Sarah LOW , Justin M. SCHEER , Leo THOMAS
摘要： The invention relates to agonistic TrkB binding molecules, methods for improving agonistic TrkB binders, their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.
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公开(公告)号：US20210380696A1
公开(公告)日：2021-12-09
申请号：US17328050
申请日：2021-05-24
发明人： David A. BLAIR , Nicole K. GARAFFA , Pankaj GUPTA , Priyanka GUPTA , Fei HAN , Aaron Timothy KARLAK , Dongmei LIU , Ivo LORENZ , Mouhamadou Lamine MBOW , Miguel E. MORENO-GARCIA , Joseph A. MOZDZIERZ , Kerry L.M. RALPH , Abdulsalam SHAABAN , Della M. WHITE , Helen Haixia WU , Guangwei YANG
IPC分类号： C07K16/28
摘要： The present invention relates to new anti-PD-1 (Programmed cell death 1) antibodies and antigen-binding fragments thereof for therapeutic and diagnostic methods and compositions using them.
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公开(公告)号：US20240336674A1
公开(公告)日：2024-10-10
申请号：US18423352
申请日：2024-01-26
发明人： Leo THOMAS , Rachel Rebecca BARRETT , Kristin Laura BOVAT , Rajkumar GANESAN , Priyanka GUPTA , Fei HAN , Dongmei LIU , Juergen PRESTLE , Sanjaya SINGH , Sathyadevi VENKATARAMANI , Helen Haixia WU , Nina ZIPPEL
CPC分类号： C07K16/18 , A61K9/0048 , C07K2317/565
摘要： The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.
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公开(公告)号：US20230416378A1
公开(公告)日：2023-12-28
申请号：US18297154
申请日：2023-04-07
发明人： Nina ZIPPEL , Pankaj GUPTA , Fei HAN , Yining HUANG , Sarah LOW , Juergen PRESTLE , Leo THOMAS
CPC分类号： C07K16/2863 , A61P27/02 , C12N15/63 , A61K9/0019
摘要： Disclosed are antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). Also disclosed are methods of using the anti-Nrp1A antibodies for the treatment of various diseases or disorders.
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公开(公告)号：US20220119535A1
公开(公告)日：2022-04-21
申请号：US17505672
申请日：2021-10-20
发明人： Peter Michael BENZ , Remko Alexander BAKKER , Holger FUCHS , Fei HAN , Sandeep KUMAR , Sarah LOW , Justin M. SCHEER , Leo THOMAS
摘要： This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.
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公开(公告)号：US20210087282A1
公开(公告)日：2021-03-25
申请号：US17030421
申请日：2020-09-24
发明人： Nina ZIPPEL , Pankaj GUPTA , Fei HAN , Yining HUANG , Sarah LOW , Juergen PRESTLE , Leo THOMAS
摘要： Disclosed are antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). Also disclosed are methods of using the anti-Nrp1A antibodies for the treatment of various diseases or disorders.
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