公开(公告)号：US20240230683A1

公开(公告)日：2024-07-11

申请号：US18560365

申请日：2022-05-13

申请人： Board of Regents of the University Of Nebraska

发明人： Howard GENDELMAN ,  R. Lee MOSLEY ,  Mai MOSTAFA ,  Katherine OLSON

IPC分类号： G01N33/68 ,  A61K31/198 ,  A61K38/17 ,  A61K38/19 ,  A61K38/22 ,  A61P25/16

CPC分类号： G01N33/6896 ,  A61K31/198 ,  A61K38/1709 ,  A61K38/193 ,  A61K38/2278 ,  A61P25/16 ,  G01N2333/4703 ,  G01N2333/916 ,  G01N2800/2835 ,  G01N2800/52

摘要： Provided are methods for monitoring the progression of Parkinson's Disease, and methods for monitoring or determining the effectiveness of therapeutics for the treatment of Parkinson's Disease, as well as methods for treatment thereof, by assessing one or more biomarkers, such as NF-κB and/or calcineurin.

公开(公告)号：US20240361339A1

公开(公告)日：2024-10-31

申请号：US18688019

申请日：2022-09-01

申请人： Board of Regents of The University of Nebraska

发明人： Howard GENDELMAN ,  R. Lee MOSLEY ,  Mai MOSTAFA ,  Katherine OLSON ,  Jatinkumar MACHHI

IPC分类号： G01N33/68 ,  A61K38/19

CPC分类号： G01N33/6896 ,  A61K38/193 ,  G01N2333/4703 ,  G01N2333/70596 ,  G01N2333/90216 ,  G01N2333/9027 ,  G01N2333/912 ,  G01N2800/2835 ,  G01N2800/52

摘要： The present disclosure relates to the treatment of Parkinson's disease with granulocyte-macrophage colony-stimulating factor, as well as diagnostic, prognostic and patient selection methods.