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公开(公告)号：US20190055240A1
公开(公告)日：2019-02-21
申请号：US16104561
申请日：2018-08-17
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Christopher Lawrence CARROLL , Jason Bryant CROSS , Zhijun KANG , Michael Garrett JOHNSON , Sarah LIVELY
IPC分类号： C07D471/04 , C07D413/14 , A61P35/00
摘要： The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
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公开(公告)号：US20190389867A1
公开(公告)日：2019-12-26
申请号：US16401047
申请日：2019-05-01
发明人： Philip JONES , Jason CROSS , Jason BURKE , Timothy MCAFOOS , Zhijun KANG
IPC分类号： C07D487/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.
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公开(公告)号：US20190282584A1
公开(公告)日：2019-09-19
申请号：US16356450
申请日：2019-03-18
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Christopher Lawrence CARROLL , Suyambu Kesava Vijayan RAMASWAMY , Zhijun KANG , Michael Garrett JOHNSON , Sarah LIVELY , David LAPOINTE
IPC分类号： A61K31/5377 , C07D471/04 , C07D413/14 , A61P35/00
摘要： The present disclosure relates to heterocyclic compounds and methods which inhibit ATR kinase to treat or prevent cancer.
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4.发明公开公开(公告)号：US20230416261A1
公开(公告)日：2023-12-28
申请号：US18461735
申请日：2023-09-06
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Timothy MCAFOOS , Christopher L. CARROLL , Zhijun KANG
IPC分类号： C07D487/04 , A61P35/00 , A61K45/06
CPC分类号： C07D487/04 , A61K45/06 , A61P35/00
摘要： Provided are ethanediamine-heterocycle compounds, and salts thereof, that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.
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公开(公告)号：US20190270736A1
公开(公告)日：2019-09-05
申请号：US16412050
申请日：2019-05-14
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC分类号： C07D417/14 , A61K31/497 , C07D493/08 , A61K31/444 , C07D403/14 , C07D405/14 , A61K31/4192 , A61K31/4439 , C07D401/14 , A61K31/501 , C07D403/06 , A61K31/433 , C07D417/06 , A61K45/06 , A61K31/454
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20240360121A1
公开(公告)日：2024-10-31
申请号：US18597265
申请日：2024-03-06
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
CPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I:
Methods of inhibition GLS1 activity in a human or animal subject are also provided.-
公开(公告)号：US20230124815A1
公开(公告)日：2023-04-20
申请号：US17660541
申请日：2022-04-25
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC分类号： C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20170291895A1
公开(公告)日：2017-10-12
申请号：US15624168
申请日：2017-06-15
发明人： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC分类号： C07D417/14 , C07D403/06 , C07D405/14 , A61K31/4192 , C07D493/08 , A61K31/4439 , C07D417/06 , C07D403/14 , A61K31/444 , A61K31/501 , C07D401/14 , A61K31/433 , A61K31/497 , A61K31/454 , A61K45/06
CPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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