公开(公告)号：US20240319175A1

公开(公告)日：2024-09-26

申请号：US18614071

申请日：2024-03-22

Applicant: Board of Regents, The University of Texas System ,  University of Vermont and State Agricultural College

Inventor： Ramkumar Menon ,  Ananth Kumar Kammala ,  Elizabeth Bonney

IPC: G01N33/50 ,  A61K35/12 ,  G16H50/30

CPC classification number: G01N33/5091 ,  A61K35/12 ,  G16H50/30 ,  G01N2800/50

Abstract: Provided herein are methods and compositions for determining an increased risk of maternal cardiovascular disease caused by an infection comprising: obtaining, or having obtained, a biological sample from a subject at risk of, of having had a pre-term birth; measuring fetal microchimeric cells or fetal extracellular vesicles in the biological sample; and using a machine learning algorithm calculating a risk of cardiovascular disease based on the an increase or a decrease in fetal microchimeric cells in the biological sample when compared to a maternal sample from a subject that does not have an infection.

公开(公告)号：US20230321195A1

公开(公告)日：2023-10-12

申请号：US18296755

申请日：2023-04-06

Applicant: Board of Regents, The University of Texas System

Inventor： Ramkumar Menon ,  Ananth Kumar Kammala ,  Enkhtuya Radnaa

IPC: A61K38/20 ,  A61P15/06

CPC classification number: A61K38/2066 ,  A61P15/06

Abstract: The present invention includes compositions and methods of treating a pregnant female subject at risk of preterm birth, comprising administering to the pregnant female subject an effective amount of an exosome that comprises a nucleic acid that expresses IL-10 or that comprises IL-10, wherein the effective amount of the IL-10 is effective to reduce, prevent or delay preterm birth