公开(公告)号：US20220143166A1

公开(公告)日：2022-05-12

申请号：US17312820

申请日：2019-10-11

Applicant: Biological E Limited

Inventor： Rajendar BURKI ,  Rajan SRIRAMAN ,  Ramesh Venkat MATUR ,  Narender Dev MANTENA ,  Mahima DATLA ,  Balamurali MASILAMANI ,  Vivek Babu KANDIMALLA ,  Veerapandu SANGAREDDY

IPC: A61K39/09

Abstract: The present invention relates to multivalent pneumococcal polysaccharide-protein conjugates vaccine composition comprising pneumococcal capsular polysaccharide of one or more Streptococcus pneumoniae serotypes conjugated to one or more carrier proteins.

公开(公告)号：US20230002468A1

公开(公告)日：2023-01-05

申请号：US17763785

申请日：2020-09-12

Applicant: Biological E Limited

Inventor： Ramesh Venkat MATUR ,  Rajan SRIRAMAN ,  Pavan Reddy REGATTI ,  Narender Dev MANTENA ,  Mahima DATLA

IPC: C07K14/605 ,  C12N15/81 ,  C12N15/77 ,  C12N15/70 ,  C12N15/75 ,  C12P21/02

Abstract: The invention relates to an N-terminal extension sequences which are employed to enhance the expression of recombinant therapeutic peptides. The invention also relates to a process for the high-level expression of recombinant therapeutic peptides using the said N-terminal extension sequence. The invention also provides nucleic acids, vectors and recombinant host cells for efficient production of biologically active proteins such as lirapeptide.