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    Use of raman spectroscopy to monitor culture medium
    2.
    发明授权
    Use of raman spectroscopy to monitor culture medium 有权

    公开(公告)号：US11249026B2

    公开(公告)日：2022-02-15

    申请号：US14775255

    申请日：2014-03-14

    Applicant: Biogen MA Inc.

    Inventor： Justin Moretto ,  Brandon Berry ,  Alex Doane

    IPC: G01N21/65 ,  G01J3/44

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM
    4.
    发明申请
    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM 审中-公开
    拉曼光谱仪用于监测培养基的使用

    公开(公告)号：US20160025633A1

    公开(公告)日：2016-01-28

    申请号：US14775255

    申请日：2014-03-14

    Applicant: BIOGEN MA INC.

    Inventor： Justin Moretto ,  Brandon Berry ,  Alex Doane

    IPC: G01N21/65

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

    Abstract translation: 一方面，本公开提供了一种限定培养组分的拉曼特征的方法，所述方法包括：获得非干扰或最小干扰溶液中培养组分的拉曼光谱，鉴定拉曼光谱中的峰，其为 与培养组分相关，获得包含培养组分的培养基的拉曼光谱，并且除去与在培养物的拉曼光谱中鉴定的峰相比变形的培养基的拉曼光谱中的培养成分的峰 在非干扰或最小干扰的解决方案中的组件。

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM
    7.
    发明公开
    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM 审中-公开

    公开(公告)号：US20230175967A1

    公开(公告)日：2023-06-08

    申请号：US17885167

    申请日：2022-08-10

    Applicant: Biogen MA Inc.

    Inventor： JUSTIN MORETTO ,  Brandon Berry ,  Alex Doane

    IPC: G01N21/65 ,  G01J3/44

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

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