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公开(公告)号：US20180353516A1
公开(公告)日：2018-12-13
申请号：US16107295
申请日：2018-08-21
发明人： Ru-Rong Ji , Tong Liu , Ines Batinic-Haberle , David S. Warner , Kimberly C. Stone , James D. Crapo
IPC分类号： A61K31/555 , A61K9/00 , A61K31/4188
CPC分类号： A61K31/555 , A61K9/0014 , A61K9/0019 , A61K31/4188
摘要： A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
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公开(公告)号：US10080759B2
公开(公告)日：2018-09-25
申请号：US15109164
申请日：2015-01-21
发明人： Ru-Rong Ji , Tong Liu , Ines Batinic-Haberle , David S. Warner , Kimberly C. Stone , James D. Crapo
IPC分类号： A61K31/555 , A61K31/4188 , A61K9/00
CPC分类号： A61K31/555 , A61K9/0014 , A61K9/0019 , A61K31/4188
摘要： A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
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公开(公告)号：US11065259B2
公开(公告)日：2021-07-20
申请号：US16107295
申请日：2018-08-21
发明人： Ru-Rong Ji , Tong Liu , Ines Batinic-Haberle , David S. Warner , Kimberly C. Stone , James D. Crapo
IPC分类号： A61K31/555 , A61K31/4188 , A61K9/00
摘要： A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
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公开(公告)号：US20190330220A1
公开(公告)日：2019-10-31
申请号：US16468911
申请日：2017-12-19
发明人： Ines Batinic-Haberle , Artak Tovmasyan , Zrinka Rajic Dzolic , Ivan Spasojevic , Christopher Allen Lee
IPC分类号： C07D487/22 , C07F13/00
摘要： Described herein are methods and intermediates useful for making substituted porphyrins, including Mn(III) orthoN-butoxyethylpyridylporphyrin, and compositions comprising the same. In some embodiments, a method of the present invention provides a composition having a certain percentage or yield (e.g., at least 80%, 85%, 90%, or 95% by weight) of a compound of the present invention.
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公开(公告)号：US20220193090A1
公开(公告)日：2022-06-23
申请号：US17691764
申请日：2022-03-10
IPC分类号： A61K31/555 , A61P35/00
摘要： Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
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公开(公告)号：US20210106594A1
公开(公告)日：2021-04-15
申请号：US16500490
申请日：2018-04-04
IPC分类号： A61K31/555 , A61P35/00
摘要： Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
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公开(公告)号：US20160324868A1
公开(公告)日：2016-11-10
申请号：US15109164
申请日：2015-01-21
发明人： Ru-Rong Ji , Tong Liu , Ines Batinic-Haberle , David S. Warner , Kimberly C. Stone , James D. Crapo
IPC分类号： A61K31/555 , A61K9/00
CPC分类号： A61K31/555 , A61K9/0014 , A61K9/0019 , A61K31/4188
摘要： A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
摘要翻译： 在有需要的受治疗者中治疗瘙痒（瘙痒）的方法是通过给予受试者一种治疗有效量的活性剂，其中活性剂是超氧化物歧化酶（SOD）模拟物。 SOD模拟物可以是金属（例如锰）和有机配体的络合物，其中合适的有机配体包括卟啉，多胺，盐，氮氧化物和富勒烯。 还描述了用于实施这些方法的组合物。
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公开(公告)号：US20240342190A1
公开(公告)日：2024-10-17
申请号：US18633760
申请日：2024-04-12
IPC分类号： A61K31/555 , A01N1/02 , A61K9/00 , A61P9/10
CPC分类号： A61K31/555 , A01N1/0226 , A61K9/0019 , A61P9/10
摘要： Described herein is a method for reducing an ischemia-reperfusion injury in a subject, the method comprising intra-arterially administering a redox active compound that comprises a metal to the subject. Also described herein is a method for increasing the time of viability of an organ awaiting transplantation and/or reducing transplant failure in a subject, the method comprising contacting the organ and a redox active compound that comprises a metal.
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公开(公告)号：US11285162B2
公开(公告)日：2022-03-29
申请号：US16500490
申请日：2018-04-04
IPC分类号： A61K31/555 , A61P35/00 , A61K9/00 , A61K31/495 , A61K33/243 , A61K45/06 , A61P17/00 , A61P43/00
摘要： Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
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公开(公告)号：US20140243294A1
公开(公告)日：2014-08-28
申请号：US14272779
申请日：2014-05-08
申请人： DUKE UNIVERSITY
发明人： Ivan Spasojevic , Michael O. Colvin , Ines Batinic-Haberle , Susan M. Ludeman , Michael P. Gamcsik
IPC分类号： A61K31/555 , A61K31/675
CPC分类号： A61K31/555 , A61K31/675 , A61K2300/00
摘要： The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
摘要翻译： 本发明提供了通过将目的化合物施用于受试者来羟化或氧化受试者中的目标化合物（例如细胞毒性恶唑磷酸前药）的方法; 并且同时给予受试者金属卟啉，所述金属卟啉有效地羟化或氧化受试者中目标化合物。
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