公开(公告)号：US07808632B2

公开(公告)日：2010-10-05

申请号：US11768040

申请日：2007-06-25

Applicant: Bikas Vaidya ,  Ulf Werner Drechsler

Inventor： Bikas Vaidya ,  Ulf Werner Drechsler

IPC: G01J3/28

CPC classification number: G01N21/33 ,  G01N1/2214 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/4738 ,  G01N21/552 ,  G01N21/658

Abstract: Method and material for spectroscopic detection of organic chemicals. The material is a substantially optically transparent solid, such as ZnS, having a high surface area for adsorption of an analyte, such as organic chemical vapors. The solid material preferably has metal nanoparticles, such as gold, silver or copper nanoparticles, deposited on the surface for signal enhancement. A template compound, such as cetyl trimethyl ammonium bromide and alkoxylate block polymers, may be used during the material synthesis, such as reacting zinc chloride and sodium sulfide in the presence of the template compound, and later removed through calcination and washing to achieve the high surface area. The method of use includes collecting an analyte on the material and detecting the spectroscopic response of the analyte while it is collected on the surface. The mechanism of collection may include adsorbing, absorbing, and preconcentrating. Preferably, the spectroscopic response is selected from infrared spectra or ultraviolet-visible spectra.

Abstract translation: 有机化学品光谱检测方法和材料。 该材料是基本上光学透明的固体，例如ZnS，具有用于吸附分析物例如有机化学蒸气的高表面积。 固体材料优选地具有金属纳米颗粒，例如金，银或铜纳米颗粒，沉积在表面上用于信号增强。 在材料合成中可以使用模板化合物，例如十六烷基三甲基溴化铵和烷氧基化物嵌段聚合物，例如在模板化合物存在下使氯化锌和硫化钠反应，然后通过煅烧和洗涤去除以达到高 表面积。 使用的方法包括在材料上收集分析物并且在被分析物收集在表面上时检测分析物的光谱响应。 收集的机制可以包括吸收，吸收和预浓缩。 优选地，光谱响应选自红外光谱或紫外 - 可见光谱。

公开(公告)号：US20080278708A1

公开(公告)日：2008-11-13

申请号：US11768040

申请日：2007-06-25

Applicant: Bikas Vaidya ,  Ulf Werner Drechsler

Inventor： Bikas Vaidya ,  Ulf Werner Drechsler

IPC: G01J3/00

CPC classification number: G01N21/33 ,  G01N1/2214 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/4738 ,  G01N21/552 ,  G01N21/658

Abstract: Method and material for spectroscopic detection of organic chemicals. The material is a substantially optically transparent solid, such as ZnS, having a high surface area for adsorption of an analyte, such as organic chemical vapors. The solid material preferably has metal nanoparticles, such as gold, silver or copper nanoparticles, deposited on the surface for signal enhancement. A template compound, such as cetyl trimethyl ammonium bromide and alkoxylate block polymers, may be used during the material synthesis, such as reacting zinc chloride and sodium sulfide in the presence of the template compound, and later removed through calcination and washing to achieve the high surface area. The method of use includes collecting an analyte on the material and detecting the spectroscopic response of the analyte while it is collected on the surface. The mechanism of collection may include adsorbing, absorbing, and preconcentrating. Preferably, the spectroscopic response is selected from infrared spectra or ultraviolet-visible spectra.

Abstract translation: 有机化学品光谱检测方法和材料。 该材料是基本上光学透明的固体，例如ZnS，具有用于吸附分析物例如有机化学蒸气的高表面积。 固体材料优选地具有金属纳米颗粒，例如金，银或铜纳米颗粒，沉积在表面上用于信号增强。 在材料合成中可以使用模板化合物，例如十六烷基三甲基溴化铵和烷氧基化物嵌段聚合物，例如在模板化合物存在下使氯化锌和硫化钠反应，然后通过煅烧和洗涤去除以达到高 表面积。 使用的方法包括在材料上收集分析物并且在被分析物收集在表面上时检测分析物的光谱响应。 收集的机制可以包括吸收，吸收和预浓缩。 优选地，光谱响应选自红外光谱或紫外 - 可见光谱。

公开(公告)号：US20100053605A1

公开(公告)日：2010-03-04

申请号：US12508721

申请日：2009-07-24

Applicant: Anthony J. Ragucci ,  Bikas Vaidya ,  Ashwin Kumar Balasubramanian ,  Mark J. Flusche

Inventor： Anthony J. Ragucci ,  Bikas Vaidya ,  Ashwin Kumar Balasubramanian ,  Mark J. Flusche

IPC: G01J3/44 ,  G01N1/22

CPC classification number: G01N21/3504 ,  G01N1/2214 ,  G01N21/658 ,  G01N30/74 ,  G01N2001/2223 ,  G01N2021/3595

Abstract: A gas sampling device, analyte detection system, and methods for identifying a vapor or aerosol analyte suspended in a gas are described. The gas sampling device comprises a chamber having a gas inlet port, a substrate, one or more gas outlet ports near the substrate, and a pump. The gas outlet ports direct airflow to a reflecting substrate coated with a spectroscopically-transparent material. Analytes are deposited on the coated substrate through impaction, for massive aerosols, and diffusion through the viscous boundary layer, for vapor analytes. In one analyte detection system, a spectroscopic instrument is positioned behind a window opposite the substrate to interrogate the coated substrate surface as analytes are collected. An alternate detection system combines the gas sampling device with a detector in fluid communication with the gas outlet ports from the chamber, wherein the substrate is used as an analyte concentrator.

Abstract translation: 描述了气体取样装置，分析物检测系统和用于识别悬浮在气体中的蒸汽或气溶胶分析物的方法。 气体采样装置包括具有气体入口端口，基板，靠近基板的一个或多个气体出口端口和泵的室。 气体出口端口将气流引导到涂有光谱透明材料的反射基板。 分析物通过冲击沉积在涂覆的基底上，用于大量气溶胶，并通过粘性边界层扩散用于蒸气分析物。 在一个分析物检测系统中，分光仪器位于与衬底相对的窗口的后面，以在分析物被收集时询问涂覆的基底表面。 替代检测系统将气体采样装置与检测器结合，该检测器与来自腔室的气体出口端口流体连通，其中基板用作分析物浓缩器。

公开(公告)号：US08758974B2

公开(公告)日：2014-06-24

申请号：US10734816

申请日：2003-12-12

Applicant: Steven A. Soper ,  Robin L. McCarley ,  Bikas Vaidya

Inventor： Steven A. Soper ,  Robin L. McCarley ,  Bikas Vaidya

IPC: G03F7/004 ,  G03F7/038 ,  G03F7/20

CPC classification number: G03F7/40 ,  B01L3/502707 ,  G01N21/7703 ,  G03F7/039 ,  G03F7/165 ,  G03F7/26

Abstract: A method is described for the direct photochemical modification and micro-patterning of polymer surfaces, without the need to use a photoresist. For example, micropatterns of various functional chemical groups, biomolecules, and metal films have been deposited on poly(carbonate) and poly(methyl methacrylate) surfaces. These patterns may be used, for example, in integrated electronics, capture elements, or sensing elements in micro-fluidic channels.

Abstract translation: 描述了用于聚合物表面的直接光化学修饰和微图案化的方法，而不需要使用光致抗蚀剂。 例如，各种功能化学基团的微图案，生物分子和金属膜已沉积在聚（碳酸酯）和聚（甲基丙烯酸甲酯）表面上。 这些图案可以用于例如微流体通道中的集成电路，捕获元件或感测元件。

公开(公告)号：US07858379B2

公开(公告)日：2010-12-28

申请号：US12132265

申请日：2008-06-03

Applicant: Bikas Vaidya

Inventor： Bikas Vaidya

IPC: G01N33/00

CPC classification number: G01N33/84 ,  Y10T436/19 ,  Y10T436/193333 ,  Y10T436/196666 ,  Y10T436/25375

Abstract: A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine. The known iodine-containing organic compound is preferably an aryl iodide, such as Iothalamate. Other preferred iodine-containing organic compounds include various glomerular filtration rate (GFR) marker compounds in plasma or urine samples, as useful in the measurement of GFR for an animal. The electrochemical reduction of the known iodine-containing organic compound is preferably performed in an electrochemical cell including a working electrode separated from a counter electrode by a cation exchange membrane. The working electrode most preferably includes bismuth and the counter electrode most preferably includes platinum.

Abstract translation: 用于测定水溶液中已知的含碘有机化合物的量的方法。 该方法包括在水性介质中电化学还原已知的含碘有机化合物以释放碘化物阴离子，化学氧化碘化物阴离子以产生分子碘，并测量分子碘的量。 已知的含碘有机化合物优选为芳基碘，例如甲硫氨酸。 其他优选的含碘有机化合物包括血浆或尿液样品中的各种肾小球滤过率（GFR）标记化合物，用于测量动物的GFR。 已知的含碘有机化合物的电化学还原优选在包括通过阳离子交换膜从对电极分离的工作电极的电化学电池中进行。 工作电极最优选包括铋，对电极最优选包括铂。

公开(公告)号：US20090017549A1

公开(公告)日：2009-01-15

申请号：US12132265

申请日：2008-06-03

Applicant: Bikas Vaidya

Inventor： Bikas Vaidya

IPC: G01N33/00

CPC classification number: G01N33/84 ,  Y10T436/19 ,  Y10T436/193333 ,  Y10T436/196666 ,  Y10T436/25375

Abstract: A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine. The known iodine-containing organic compound is preferably an aryl iodide, such as Iothalamate. Other preferred iodine-containing organic compounds include various glomerular filtration rate (GFR) marker compounds in plasma or urine samples, as useful in the measurement of GFR for an animal. The electrochemical reduction of the known iodine-containing organic compound is preferably performed in an electrochemical cell including a working electrode separated from a counter electrode by a cation exchange membrane. The working electrode most preferably includes bismuth and the counter electrode most preferably includes platinum.

Abstract translation: 用于测定水溶液中已知的含碘有机化合物的量的方法。 该方法包括在水性介质中电化学还原已知的含碘有机化合物以释放碘化物阴离子，化学氧化碘化物阴离子以产生分子碘，并测量分子碘的量。 已知的含碘有机化合物优选为芳基碘，例如甲硫氨酸。 其他优选的含碘有机化合物包括血浆或尿液样品中的各种肾小球滤过率（GFR）标记化合物，用于测量动物的GFR。 已知的含碘有机化合物的电化学还原优选在包括通过阳离子交换膜从对电极分离的工作电极的电化学电池中进行。 工作电极最优选包括铋，对电极最优选包括铂。