公开(公告)号：US11912876B2

公开(公告)日：2024-02-27

申请号：US17126961

申请日：2020-12-18

Applicant: Becton, Dickinson and Company

Inventor： Yongchao Liang ,  Haiqing Li ,  Brent S. Gaylord

IPC: C09K8/28 ,  C09B69/10 ,  C08G61/12 ,  C09B69/00 ,  G01N33/58

CPC classification number: C09B69/10 ,  C08G61/124 ,  C08G61/126 ,  C09B69/00 ,  C08G2261/148 ,  C08G2261/1424 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3241 ,  C08G2261/3243 ,  C08G2261/3246 ,  C08G2261/344 ,  C08G2261/41 ,  C08G2261/411 ,  C08G2261/414 ,  C08G2261/522 ,  C08G2261/72 ,  G01N33/582

Abstract: Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

公开(公告)号：US20210108083A1

公开(公告)日：2021-04-15

申请号：US17126961

申请日：2020-12-18

Applicant: Becton, Dickinson and Company

Inventor： Yongchao Liang ,  Haiqing Li ,  Brent S. Gaylord

IPC: C09B69/10 ,  C08G61/12 ,  C09B69/00

Abstract: Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

公开(公告)号：US20180009989A1

公开(公告)日：2018-01-11

申请号：US15642255

申请日：2017-07-05

Applicant: Becton, Dickinson and Company

Inventor： Yongchao Liang ,  Haiqing Li ,  Brent S. Gaylord

IPC: C09B69/10 ,  G01N33/58 ,  C08G61/12

CPC classification number: C09B69/10 ,  C08G61/124 ,  C08G61/126 ,  C08G2261/1424 ,  C08G2261/148 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3241 ,  C08G2261/3243 ,  C08G2261/3246 ,  C08G2261/344 ,  C08G2261/41 ,  C08G2261/411 ,  C08G2261/414 ,  C08G2261/522 ,  C08G2261/72 ,  C09B69/00 ,  G01N33/582

Abstract: Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

公开(公告)号：US20240240025A1

公开(公告)日：2024-07-18

申请号：US18411706

申请日：2024-01-12

Applicant: Becton, Dickinson and Company

Inventor： Yongchao Liang ,  Haiqing Li ,  Brent S. Gaylord

IPC: C09B69/10 ,  C08G61/12 ,  C09B69/00 ,  G01N33/58

CPC classification number: C09B69/10 ,  C08G61/124 ,  C08G61/126 ,  C09B69/00 ,  C08G2261/1424 ,  C08G2261/148 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3241 ,  C08G2261/3243 ,  C08G2261/3246 ,  C08G2261/344 ,  C08G2261/41 ,  C08G2261/411 ,  C08G2261/414 ,  C08G2261/522 ,  C08G2261/72 ,  G01N33/582

Abstract: Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

公开(公告)号：US10920082B2

公开(公告)日：2021-02-16

申请号：US15642255

申请日：2017-07-05

Applicant: Becton, Dickinson and Company

Inventor： Yongchao Liang ,  Haiqing Li ,  Brent S. Gaylord

IPC: C08G61/12 ,  C09B69/10 ,  C09B69/00 ,  G01N33/58

Abstract: Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.