公开(公告)号：US20240287453A1

公开(公告)日：2024-08-29

申请号：US18441740

申请日：2024-02-14

Applicant: Beam Therapeutics Inc.

Inventor： Colby MALDINI ,  Angelica MESSANA ,  Jason Michael GEHRKE ,  Leila PERARO ,  Lauren YOUNG

IPC: C12N5/078 ,  A61K35/17 ,  C12N15/11 ,  C12N15/85

CPC classification number: C12N5/0634 ,  A61K35/17 ,  C12N15/111 ,  C12N15/85 ,  C12N2510/00

Abstract: The present disclosure features allogeneic modified immune cells (e.g., T- or NK-cells) having increased persistence, increased resistance to immune rejection, or decreased risk of eliciting a host-versus-graft reaction, or a combination thereof. Methods for producing and using the same are also provided.