公开(公告)号：US20240158355A1

公开(公告)日：2024-05-16

申请号：US18262037

申请日：2022-01-19

申请人： Baylor College of Medicine

发明人： Martin Matzuk ,  Zhifeng Yu ,  Angela Ku ,  Justin Anglin ,  Feng Li ,  Damian Young ,  Ying-Chu Chen ,  Melek Ucisik ,  John Faver ,  Stephen Palmer ,  Rajesh Sharma ,  Choel Kim

IPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04

摘要： In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.

公开(公告)号：US20200048716A1

公开(公告)日：2020-02-13

申请号：US16180046

申请日：2018-11-05

申请人： Twister Biotech, Inc ,  Baylor College of Medicine

发明人： E. Lynn Zechiedrich ,  Martin M. Matzuk ,  Laising Yen ,  Zhifeng Yu ,  Lirio Milenka Arevalo-Soliz ,  Daniel James Catanese, JR. ,  Jonathan Marcus Fogg ,  Christopher Elbert Coker

IPC分类号： C12Q1/6886 ,  A61K48/00 ,  A61P35/00 ,  C12N15/64

摘要： MiniVectors and compositions containing MiniVectors that target ovarian cancer genes selected from FOXM1, AKT, CENPA, PLK1, CDC20, BIRC5, AURKB, CCNB1, CDKN3, BCAM-AKT2, CDKN2D-WDFY2, SLC25A6, CIP2A, CD133, ALDH1A1, CD44, SALL4, and/or PRDM16, alone or in any combination, are provided, along with uses in the treatment of ovarian cancer.