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公开(公告)号：US20240342312A1
公开(公告)日：2024-10-17
申请号：US18580421
申请日：2022-08-03
IPC分类号： A61K48/00 , A61K38/17 , A61K38/18 , A61K45/06 , A61P9/04 , C07K14/82 , C07K16/18 , C12N15/113 , C12N15/86
CPC分类号： A61K48/0058 , A61K38/1709 , A61K38/1866 , A61K45/06 , A61K48/0033 , A61K48/0075 , A61P9/04 , C07K14/82 , C07K16/18 , C12N15/113 , C12N15/86 , C12N2310/14 , C12N2310/531 , C12N2740/15043
摘要： Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63-TID and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5, and/or one or more of ETV2 and VEGF. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63-TID and one or both of the transcription factors Hand2 and myocardin.
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公开(公告)号：US12031135B2
公开(公告)日：2024-07-09
申请号：US17813493
申请日：2022-07-19
发明人： Vivekkumar B. Patel , Hongran Wang , Vivek P. Singh , Erin Lynn Reineke , Megumi Mathison , Austin J. Cooney , Todd Rosengart
IPC分类号： C12N15/86 , A61K9/00 , A61K31/47 , A61K31/713 , A61K38/17 , A61K48/00 , C07K14/47 , C07K14/82 , C12N5/077 , C12N15/113
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/47 , A61K31/713 , A61K38/1709 , A61K48/0058 , C07K14/4702 , C07K14/4746 , C07K14/82 , C12N5/0657 , C12N15/1135 , C12N15/86 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2501/60 , C12N2710/10043 , C12N2740/15043 , C12N2310/14 , C12N2310/531
摘要： Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.
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公开(公告)号：US20220143142A1
公开(公告)日：2022-05-12
申请号：US17593286
申请日：2020-03-17
发明人： Megumi Mathison , Todd Rosengart , Vivek P. Singh , Deepthi Sanagasetti , Jaya Pratap Pinnamaneni , Jianchang Yang
摘要： Embodiments of the disclosure provide methods and compositions related to improving cardiomyocyte production by exposing starting cells to ETV2 and/or VEGF. The starting cells in specific embodiments are fibroblasts and/or endothelial cells, and following exposure to ETV2 and/or VEGF the resultant cells are exposed to one or more cardiomyocyte transdifferentiation factors, such as GATA4, myocyte enhancer factor-2c (Mef2c), T-box transcription factor 5 (TBX5), or a combination thereof. The produced cardiomyocytes are provided to individuals in need thereof, in particular embodiments.
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公开(公告)号：US20220348921A1
公开(公告)日：2022-11-03
申请号：US17813493
申请日：2022-07-19
发明人： Vivekkumar B. Patel , Hongran Wang , Vivek P. Singh , Erin Lynn Reineke , Megumi Mathison , Austin J. Cooney , Todd Rosengart
IPC分类号： C12N15/113 , C07K14/47 , C07K14/82 , C12N5/077 , A61K9/00 , A61K31/47 , A61K31/713 , A61K38/17 , A61K48/00 , C12N15/86
摘要： Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.
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公开(公告)号：US11421229B2
公开(公告)日：2022-08-23
申请号：US15552253
申请日：2016-02-19
发明人： Vivekkumar B. Patel , Hongran Wang , Vivek P. Singh , Erin Lynn Reineke , Megumi Mathison , Austin J. Cooney , Todd Rosengart
IPC分类号： C12N15/113 , A61K38/17 , A61K31/47 , C07K14/47 , C07K14/82 , C12N5/077 , A61K9/00 , A61K31/713 , A61K48/00 , C12N15/86
摘要： Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.
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公开(公告)号：US20180066252A1
公开(公告)日：2018-03-08
申请号：US15552253
申请日：2016-02-19
发明人： Vivekkumar B. Patel , Hongran Wang , Vivek P. Singh , Erin Lynn Reineke , Megumi Mathison , Austin J. Cooney , Todd Rosengart
IPC分类号： C12N15/113 , A61K38/17 , A61K9/00 , A61K31/47 , A61K31/713 , C12N15/86 , A61K48/00
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/47 , A61K31/713 , A61K38/1709 , A61K48/0058 , C07K14/4702 , C07K14/4746 , C07K14/82 , C12N5/0657 , C12N15/1135 , C12N15/86 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2501/60 , C12N2710/10043 , C12N2740/15043
摘要： Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.
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