公开(公告)号：US20170305912A1

公开(公告)日：2017-10-26

申请号：US15507716

申请日：2015-08-28

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Holger PAULSEN ,  Uwe MÜNSTER ,  Nicolas GUIMOND

IPC: C07D487/04 ,  C07B41/02

CPC classification number: C07D487/04 ,  C07B41/02

Abstract: A process for the preparation of 3-phenyl/heteroaryl-6-phenoxy-8-alkylamino-imidazo[1,2-b]pyridazine derivatives and intermediates of this process. A crystalline form of N-cyclopropyl-4-{6-(2,3-difluor-4-methoxyphenoxy)-8-[(3,3,3-trifluorpropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide. The compounds are inhibitors of the Mps-1 kinase (Monopolar Spindle 1 kinase; also known as Tyrosine Threonine Kinase, TTK).

公开(公告)号：US20190152944A1

公开(公告)日：2019-05-23

申请号：US16097506

申请日：2017-04-25

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Tobias THALER ,  Johannes PLATZEK ,  Nicolas GUIMOND

IPC: C07D401/12 ,  A61K9/20

Abstract: The present invention relates to crystalline forms of N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide, to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the control of disorders.

公开(公告)号：US20190112270A1

公开(公告)日：2019-04-18

申请号：US16097067

申请日：2017-04-25

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Tobias THALER ,  Johannes PLATZEK ,  Nicolas GUIMOND

IPC: C07D213/81

Abstract: The present invention relates to crystalline forms of N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide, to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the control of disorders.

公开(公告)号：US20190144420A1

公开(公告)日：2019-05-16

申请号：US16097463

申请日：2017-04-25

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Tobias THALER ,  Johannes PLATZEK ,  Nicolas GUIMOND

IPC: C07D401/12

Abstract: The present invention relates to a novel method of preparing a 2-substituted indazole of formula (I) to novel intermediate compounds, and to the use of intermediate compounds for the preparation of said 2-substituted indazole.

公开(公告)号：US20190106407A1

公开(公告)日：2019-04-11

申请号：US16097065

申请日：2017-04-25

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Tobias THALER ,  Johannes PLATZEK ,  Nicolas GUIMOND

IPC: C07D401/12 ,  C07D231/56 ,  C07D213/54

Abstract: The present invention relates to a novel method of preparing a 2-substituted indazole of structure: (I), to intermediate compounds, and to the use of intermediate compounds for the preparation of said 2-substituted indazole.