公开(公告)号：US20220098201A1

公开(公告)日：2022-03-31

申请号：US17310347

申请日：2020-01-27

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

Inventor： Jörg GRIES ,  Johannes PLATZEK ,  Claus-Christian HÄSELHOFF ,  Kai LOVIS

IPC: C07D487/04

Abstract: Compound (III) which is the crystalline form of [4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2, -f] [1,2,4]triazin-7-yl]methyl}piperazin-2-one hydrochloride] which is the monohydrate, processes for its preparation, pharmaceutical compositions comprising it and its use in the control of disorders, including cancer.

公开(公告)号：US20220356194A1

公开(公告)日：2022-11-10

申请号：US17691858

申请日：2022-03-10

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Jörg GRIES ,  Johannes PLATZEK

IPC: C07F5/02 ,  C07D333/54 ,  C07D333/72 ,  C07D487/04

Abstract: A process for preparing the benzothiophen-2-yl boronate of formula (VI) which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of proliferative disorders, such as cancer and tumor diseases.

公开(公告)号：US20200339606A1

公开(公告)日：2020-10-29

申请号：US16759139

申请日：2018-10-18

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Jörg GRIES ,  Johannes PLATZEK

IPC: C07F5/02 ,  C07D333/72 ,  C07D333/54 ,  C07D487/04

Abstract: A process for preparing the benzothiophen-2-yl boronate of formula (VI) which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of proliferative disorders, such as cancer and tumor diseases.