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公开(公告)号：US20160007604A1
公开(公告)日：2016-01-14
申请号：US14772471
申请日：2014-02-27
发明人： Michael MAUE , Anne DECOR , Thomas BRETSCHNEIDER , Julia Johanna HAHN , Werner HALLENBACH , Reiner FISCHER , Hans-Georg SCHWARZ , Ulrich GÖRGENS , Kerstin ILG , Klaus RAMING , Johannes KÖBBERLING , Walter HÜBSCH , Andreas TURBERG
IPC分类号： A01N43/56 , C07D231/12
CPC分类号： A01N43/56 , A01N43/647 , A01N43/653 , C07D231/12 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The invention relates inter alia to halogen-substituted compounds of the general formula (II) in which the radicals A1-A4, T, n, W, Q, R1 and Z1-Z3 have the meanings given in the description. Also described are processes for preparing the compounds of the formula (II). The compounds according to the invention are particularly suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.
摘要翻译： 本发明尤其涉及通式（II）的卤素取代的化合物，其中基团A1-A4，T，n，W，Q，R1和Z1-Z3具有在说明书中给出的含义。 还描述了制备式（II）化合物的方法。 根据本发明的化合物特别适用于在兽医学中控制农业和外寄生虫中的昆虫，蜘蛛和线虫。
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公开(公告)号：US20200024264A1
公开(公告)日：2020-01-23
申请号：US16348797
申请日：2017-11-06
发明人： Walter HÜBSCH , Johannes KÖBBERLING , Adeline KÖHLER , Hans-Georg SCHWARZ , Daniel KULKE , Claudia WELZ , Thomas ILG , Kirsten BÖRNGEN , Wei ZHUANG , Nils GRIEBENOW , Claudia BÖHM , Niels LINDNER , Maike HINK , Ulrich GÖRGENS
IPC分类号： C07D405/14 , A61P33/10 , C07D405/12 , C07D413/14
摘要： The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210139468A1
公开(公告)日：2021-05-13
申请号：US17053680
申请日：2019-05-07
发明人： Walter HÜBSCH , Nils GRIEBENOW , Hans-Georg SCHWARZ , Daniel KULKE , Claudia BÖHM , Kirsten BÖRNGEN , Bernd ALIG , Wei ZHUANG , Iring HEISLER , Thomas ILG , Johannes KÖBBERLING , Adeline KÖHLER , Niels LINDNER , Ulrich GÖRGENS , Claudia WELZ , Maike HINK
IPC分类号： C07D405/14 , A61P33/10 , C07D405/12
摘要： The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210130315A1
公开(公告)日：2021-05-06
申请号：US16762068
申请日：2018-11-06
发明人： Dirk HEIMBACH , Satoshi OMURA , Toshiaki SUNAZUKA , Tomoyasu HIROSE , Yoshihiko NOGUCHI , Johannes KÖBBERLING , Zhijie WU , Shuibiao FU , Wei WU , Jinfeng QIU , Liu HE , Xudong WEI
IPC分类号： C07D325/00 , A61K38/15
摘要： The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.
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公开(公告)号：US20210115026A1
公开(公告)日：2021-04-22
申请号：US17085880
申请日：2020-10-30
发明人： Walter HÜBSCH , Johannes KÖBBERLING , Adeline KÖHLER , Hans-Georg SCHWARZ , Daniel KULKE , Claudia WELZ , Thomas ILG , Kirsten BÖRNGEN , Wei ZHUANG , Nils GRIEBNOW , Claudia BÖHM , Niels LINDNER , Maike HINK , Ulrich GÖRGENS
IPC分类号： C07D405/14 , C07D413/14 , C07D405/12 , A61P33/10
摘要： The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200230204A1
公开(公告)日：2020-07-23
申请号：US16486724
申请日：2018-02-14
IPC分类号： A61K38/15 , A61K31/702 , A61K9/00 , A61P31/04
摘要： The present invention relates to the combination of lysobactin with an aminoglycoside antibiotic for use in the treatment of diseases caused by Gram-positive and Gram-negative bacteria in non-human animals. The invention proved to be particularly useful relating to the treatment of mastitis in non-human animals. Particularly bovine mastitis can be well addressed by the present invention.
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公开(公告)号：US20190071447A1
公开(公告)日：2019-03-07
申请号：US16093565
申请日：2017-04-10
发明人： Adeline KÖHLER , Claudia WELZ , Kirsten BÖRNGEN , Daniel KULKE , Thomas ILG , Johannes KÖBBERLING , Walter HÜBSCH , Hans-Georg SCHWARZ , Ulrich GÖRGENS , Ulrich EBBINGHAUS-KINTSCHER , Maike HINK , Dirk NENNSTIEL , Klaus RAMING , Martin ADAMCZEWSKI , Claudia BÖHM
IPC分类号： C07D487/04 , A61P33/10
摘要： The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20160326140A1
公开(公告)日：2016-11-10
申请号：US15109630
申请日：2014-12-30
发明人： Hans-Georg SCHWARZ , Michael MAUE , Kerstin ILG , Ulrich GÖRGENS , Andreas TURBERG , Sebastian HORSTMANN , Johannes KÖBBERLING , Niels LINDNER
IPC分类号： C07D403/04 , A01N43/56 , C07D409/14 , A01N43/90 , C07D413/14 , A01N43/76 , C07D407/14 , C07D487/04 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , A01N43/56 , A01N43/76 , A01N43/90 , C07D231/38 , C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D487/04
摘要： The invention comprises, inter alia, pyrazolylheteroarylamides of the general formula (I) in which the A1-A4, T, W, Q, R1 and Z1-Z3 radicals are each as defined in the description. Also described are processes for preparing the compounds of the formula (I). The inventive compounds are especially suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.
摘要翻译： 其中A1-A4，T，W，Q，R1和Z1-Z3基团各自如说明书中所定义。 还描述了制备式（I）化合物的方法。 本发明化合物特别适用于控制农药中的昆虫，蜘蛛和线虫，并在兽医学中控制外寄生虫。
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