公开(公告)号：US20250066358A1

公开(公告)日：2025-02-27

申请号：US18718012

申请日：2022-12-09

Applicant: Bala Therapeutics, Inc.

Inventor： Ruben Abagyan ,  Vladislav Zenonovich Parchinsky ,  Alexander Khvat ,  Alexandre Vasilievich Ivachtchenko ,  Nikolay Savchuk

IPC: C07D471/10 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/554 ,  C07D401/12 ,  C07D403/12 ,  C07D519/00

Abstract: The present invention is directed to the compounds of Formula (I)—inhibitors of the interaction of menin and MLL. The inhibitors described herein can be useful in the treatment of diseases or disorders associated with menin-MLL interaction, such as cancer. In particular, the invention is concerned with compounds and pharmaceutical compositions inhibiting/blocking menin-MLL interaction, methods of treating diseases or disorders associated with menin-MLL interaction, and methods of synthesizing these compounds.