公开(公告)号：US11173219B2

公开(公告)日：2021-11-16

申请号：US16520965

申请日：2019-07-24

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie LaFont ,  Daniel Cohen

IPC分类号： A61K51/08 ,  C07K14/78 ,  G01N33/574 ,  C12N5/00 ,  C12N15/09 ,  G01N33/60 ,  G01N33/68

摘要： Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

公开(公告)号：US11344639B2

公开(公告)日：2022-05-31

申请号：US16305284

申请日：2017-05-31

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen ,  David K. Leung

IPC分类号： A61K51/08 ,  C07B59/00 ,  C07K16/28

摘要： Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

公开(公告)号：US10406251B2

公开(公告)日：2019-09-10

申请号：US15529260

申请日：2015-11-24

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria N. Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen

IPC分类号： A61K51/08 ,  C07K14/78 ,  G01N33/60 ,  G01N33/68 ,  G01N33/574

摘要： Provided herein are novel polypeptides comprising fibronectin type III tenth (10Fn3) domains which specifically bind to Programmed Death Ligand-1 (PD-L1), as well as imaging agents based on the same for diagnostics.

公开(公告)号：US09987381B2

公开(公告)日：2018-06-05

申请号：US15032486

申请日：2014-10-31

申请人： BRISTOL-MYERS SQUIBB COMPANY ,  YALE UNIVERSITY

发明人： Thomas Jon Seiders ,  David J. Donnelly ,  Samuel J. Bonacorsi, Jr. ,  Kai Cao ,  Tritin Tran ,  Adrienne Pena ,  Joonyoung Kim ,  Richard E. Carson ,  Nabeel Nabulsi ,  Jean-Dominique Gallezot ,  Yiyun Huang ,  Jeffrey Roger Roppe

IPC分类号： A61K51/04 ,  C07D261/14 ,  C07B59/00 ,  A61B6/00

CPC分类号： A61K51/0453 ,  A61B6/481 ,  C07B59/002 ,  C07B2200/05 ,  C07D261/14

摘要： The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.