公开(公告)号：US20200131200A1

公开(公告)日：2020-04-30

申请号：US16739363

申请日：2020-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Leon M. Smith, II ,  Vladimir Ladziata ,  Indawati De Lucca ,  Donald J.P. Pinto ,  Michael J. Orwat ,  Andrew K. Dilger ,  Kumar Balashnmuga Pabbisetty ,  Wu Yang ,  Scott A. Shaw ,  Peter W. Glunz ,  Manoranjan Panda

IPC: C07D513/04 ,  A61P9/10 ,  A61P15/10 ,  C07D213/64 ,  C07D231/12 ,  C07D401/14 ,  C07D231/54 ,  C07D401/12 ,  C07D413/12 ,  C07D471/12 ,  C07D471/04 ,  C07D231/18

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.