公开(公告)号：US09371328B2

公开(公告)日：2016-06-21

申请号：US14191861

申请日：2014-02-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Brian E. Fink ,  Libing Chen ,  Ashvinikumar V. Gavai ,  Liqi He ,  Soong-Hoon Kim ,  Andrew James Nation ,  Yufen Zhao ,  Litai H. Zhang

IPC: C07D487/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。

公开(公告)号：US20140179674A1

公开(公告)日：2014-06-26

申请号：US14191861

申请日：2014-02-27

Applicant: Bristol-Myers Squibb Company

Inventor： Brian E. Fink ,  Libing Chen ,  Ashvinikumar V. Gavai ,  Liqi He ,  Soong-Hoon Kim ,  Andrew James Nation ,  Yufen Zhao ,  Litai H. Zhang

IPC: C07D487/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。