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公开(公告)号：US10894059B2
公开(公告)日：2021-01-19
申请号：US16605731
申请日：2017-12-22
发明人： Rongzhao Fu , Xieguo Yan , Zhu Dai
IPC分类号： A61K31/7084 , A61K9/00 , A61K9/20 , A61K31/205
摘要： An NADH compound, and a formulation and use thereof, relating to the technical field of biomedicine and health care products. The NADH compound includes NADH or its physiologically acceptable salt and L-carnitine or its physiologically acceptable salt, and can be used as a weight loss product. The NADH compound has an increased effect in weight loss, and may achieve long-term drug administration of the product.
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公开(公告)号：US10214556B2
公开(公告)日：2019-02-26
申请号：US15109956
申请日：2015-12-04
发明人： Rongzhao Fu , Zhu Dai , Qi Zhang
IPC分类号： C07H1/06 , C07H19/207
摘要： A method for purifying a salt of reduced form of β-nicotinamide adenine dinucleotide (NADH) includes: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction, collecting a concentrate for use; adding an ion pair reagent to the concentrate, and purifying by gradient elution to obtain a purified filtrate using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase A, and ethanol as a phase B; changing the cations in the purified filtrate into sodium ions to obtain a filtrate by using a cation exchange resin; and nanofiltrating the filtrate, and freeze drying in a vacuum freeze drier. The method results in an excellent purity and yield of a salt of NADH that meets requirements in industry.
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公开(公告)号：US10214552B2
公开(公告)日：2019-02-26
申请号：US15110005
申请日：2015-12-02
发明人： Rongzhao Fu , Zhu Dai , Qi Zhang
IPC分类号： C07H19/20 , C07H1/06 , C07H19/048
摘要： A method for purifying β-nicotinamide mononucleotide (NMN) includes: sequentially microfiltrating and nanofiltrating a crude product solution containing NMN using membrane concentration devices to obtain a concentrated crude product solution; adjusting the concentrated crude product solution to pH 3-7 to obtain a loading solution, loading the loading solution onto a preparative reverse phase high performance liquid chromatographic column, and purifying by gradient elution using an octadecylsilane-bonded silica gel as a stationary phase, a hydrochloric acid solution at pH 3-7 as a mobile phase A, and 100% ethanol as a mobile phase B, to obtain a purified sample solution; concentrating the purified sample solution by nanofiltration and freeze drying in a vacuum freeze drier to obtain a purified NMN.
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