公开(公告)号：US20240174755A1

公开(公告)日：2024-05-30

申请号：US17760252

申请日：2021-02-05

Applicant: BIORION TECHNOLOGIES B.V.

Inventor： Hermannus STEEN ,  Gustaaf Johan Marie VAN SCHARRENBURG

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10

CPC classification number: C07K16/2863 ,  A61K45/06 ,  A61K47/6849 ,  A61K49/0002 ,  A61K51/103 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/569

Abstract: The invention relates to antibodies against the Platelet Derived Growth Factor Receptor beta (PDGFR β), and the use thereof in diagnostic and/or therapeutic applications. In particular, it provides a (VHH) antibody that specifically binds PDGFR β with an apparent binding affinity of less than 10 nM, preferably less than 5 nM, and which does not activate PDGFR β. Also provided are PDGFR β antibodies and conjugates thereof, and their application in the targeted delivery of a diagnostic agent, a therapeutic agent or a combination thereof to a tissue in a subject, in particular to fibrotic tissue comprising activated myofibroblasts.