公开(公告)号：US20240360157A1

公开(公告)日：2024-10-31

申请号：US18260275

申请日：2022-01-06

Applicant: BIOGEN MA INC.

Inventor： Nathan Genung ,  Tamara Halkina Levin

IPC: C07D519/00 ,  A61K31/5025 ,  A61K31/53

CPC classification number: C07D519/00 ,  A61K31/5025 ,  A61K31/53

Abstract: This disclosure relates to compounds of formula (I′), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the application. The compounds of the present disclosure are capable of inhibiting the activity of tyrosine kinase 2 (TYK2). The disclosure further provides methods of preparing the compounds of the disclosure, and methods for their therapeutic use.