公开(公告)号：US10251847B2

公开(公告)日：2019-04-09

申请号：US15536603

申请日：2015-12-16

Applicant: BIOELECTRON TECHNOLOGY CORPORATION

Inventor： Paul Mollard ,  Christopher R. Cornell ,  Kieron E. Wesson ,  Peter Giannousis ,  Shazad Suchit ,  Mahmoud Mirmehrabi

IPC: C07C215/08 ,  C07C215/18 ,  C07C215/30 ,  C07C231/12 ,  C07C235/78 ,  A61K31/164 ,  A61K31/122 ,  C07C215/28 ,  C07B57/00

Abstract: Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.