公开(公告)号：US20220378799A1

公开(公告)日：2022-12-01

申请号：US17616571

申请日：2020-06-05

Applicant: BEIJING TIDE PHARMACEUTICAL CO., LTD.

Inventor： Yanping Zhao ,  Hongjun Wang ,  Bin Liu ,  Yuanyuan Jiang ,  Weiting Zhong ,  Huifen Xu ,  Honglei Zhang ,  Chuangchuang Huang ,  Nana Tian ,  Jing Zhao ,  Jing Li ,  Weina Liu ,  Liying Zhou ,  Yanan Liu

IPC: A61K31/5377 ,  C07D471/04 ,  C07D413/14 ,  A61P35/00

Abstract: Compounds of general formula (A) can be used for treating ATR kinase-mediated diseases, for example, hyperplastic diseases such as cancers. Also provided are a pharmaceutical composition of the compounds of general formula (A), a use of the pharmaceutical composition for treating the ATR kinase-mediated diseases and a preparation method for the pharmaceutical composition.

公开(公告)号：US20230212160A1

公开(公告)日：2023-07-06

申请号：US17926533

申请日：2021-05-20

Applicant: BEIJING TIDE PHARMACEUTICAL CO., LTD.

Inventor： Yanping Zhao ,  Bin Liu ,  Yuanyuan Jiang ,  Weiting Zhong ,  Huifen Xu ,  Hongjun Wang ,  Li Mao ,  Jingtao Li ,  Honglei Zhang ,  Chuangchuang Huang ,  Jing .. Li ,  Jing Zhao ,  Weina Liu ,  Nana Tian ,  Liying Zhou ,  Yanan Liu

IPC: C07D413/14 ,  C07D471/04 ,  C07D405/14 ,  A61P35/02 ,  A61P15/08 ,  A61P35/00

CPC classification number: C07D413/14 ,  A61P15/08 ,  A61P35/00 ,  A61P35/02 ,  C07D405/14 ,  C07D471/04

Abstract: Provided are compounds represented by general formula (I), which can be used for treating ATR kinase-mediated diseases, such as proliferative diseases, such as cancer. Further provided are a pharmaceutical composition of the compound represented by general formula (I), a use thereof in treating ATR kinase-mediated diseases, and a preparation thereof.