公开(公告)号：US20250149110A1

公开(公告)日：2025-05-08

申请号：US18929408

申请日：2024-10-28

Applicant: BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.

Inventor： Kunrui Zhu ,  Lihang Liu ,  Xiaomin Fang ,  Xiaonan Zhang ,  Jingzhou He

IPC: G16B15/20 ,  G16B40/00

Abstract: A method for predicting a structure of a protein complex includes: obtaining an initial coordinate of each amino acid residue in a target protein complex, and obtaining a target residue pair feature, a first multiple sequence alignment (MSA) feature and a second MSA feature of each protein monomer in the target protein complex; and inputting the initial coordinate of each amino acid residue, and the target residue pair feature, the first MSA feature and the second MSA feature of each protein monomer into an N-level fold iteration network layer, and obtaining a target coordinate of each amino acid residue by predicting a torsion angle, a position transformation at residue level and a position transformation at monomer chain level of each amino acid residue via the N level fold iteration network layer, to obtain a predicted structure of the protein complex.

公开(公告)号：US20250104803A1

公开(公告)日：2025-03-27

申请号：US18972078

申请日：2024-12-06

Applicant: BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.

Inventor： Kunrui Zhu ,  Lihang Liu ,  Xiaomin Fang ,  Xiaonan Zhang ,  Jingzhou He

IPC: G16B15/20 ,  G06F30/27 ,  G16B30/00 ,  G16B40/20

Abstract: A method for information processing, is performed by an electronic device, and the method includes: obtaining a residue sequence AT that does not carry amino acid information and a first protein backbone structure BT generated by pure noise; and performing iterative denoising on the residue sequence AT and the first protein backbone structure BT; for a tth denoising, obtaining coevolution information of a residue sequence AT+1−t, and obtaining, based on the coevolution information and a first protein backbone structure BT+1−t, a residue sequence AT−t and a first protein backbone structure BT−t after the tth denoising, until the denoising is completed and a target amino acid sequence and a second protein backbone structure are obtained, where t is a positive integer, and 1≤t≤T, and T is a number of denoising times.