公开(公告)号：US20240352139A1

公开(公告)日：2024-10-24

申请号：US18036144

申请日：2021-11-11

申请人： BEIJING IMMUNOAH PHARMATECH CO., LTD.

发明人： Xin GAO ,  Niliang QIAN ,  Xiujie PAN ,  Guili XU ,  Yujie LIU ,  Hongjie LI ,  Cuima YANG ,  Qinzhi XU ,  Xiaoqian DOU ,  Yunhui LIU ,  Zhenjun YU ,  Guijun BAI

IPC分类号： C07K16/28 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/30 ,  C07K16/3007 ,  C07K16/3069 ,  C07K16/3084 ,  C07K16/3092 ,  C07K2317/21 ,  C07K2317/31

摘要： The present application provides a fusion protein, containing: an anti-CD137 antibody capable of specifically binding to a CD137 molecule or an antigen binding fragment thereof; an anti-CD3 antibody capable of specifically binding to a CD3 molecule or an antigen binding fragment thereof; and a first peptide linker and a second peptide linker. The present application also provides a nucleic acid encoding the fusion protein, an expression vector containing the nucleic acid, a host cell containing the nucleic acid or the expression vector, a method for preparing the fusion protein, a pharmaceutical composition containing the fusion protein, and a use of the fusion protein.