公开(公告)号：US20190062326A1

公开(公告)日：2019-02-28

申请号：US15756867

申请日：2016-12-07

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Heinrich MEIER ,  Klemens LUSTIG ,  Johanna MOSIG ,  Luisella TOSCHI ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC: C07D471/04 ,  A61K31/496 ,  A61K45/06 ,  A61P11/16

Abstract: The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

公开(公告)号：US20180370965A1

公开(公告)日：2018-12-27

申请号：US15781848

申请日：2016-12-02

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Heinrich MEIER ,  Klemens LUSTIG ,  Johanna MOSIG ,  Luisella TOSCHI ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P11/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P11/00 ,  C07D519/00

Abstract: The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.