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    Anti-sema3a antibodies and uses thereof
    2.
    发明授权
    Anti-sema3a antibodies and uses thereof 有权

    公开(公告)号：US12173068B2

    公开(公告)日：2024-12-24

    申请号：US18399934

    申请日：2023-12-29

    Applicant: BAYER AKTIENGESELLSCHAFT

    Inventor： Dorian Schönfeld ,  Karoline Dröbner ,  Ernst Weber ,  Katharina Filarsky ,  Philipp Ellinger ,  Fionnuala Mary McAleese Eser ,  Ingo Flamme ,  Winfried Wunderlich ,  Antje Schmidt ,  Yalda Sedaghat ,  Kenneth Young

    IPC: C07K16/28 ,  A61K39/395 ,  A61P9/10 ,  A61P13/12 ,  C07K16/18 ,  A61K39/00

    Abstract: The present disclosure relates to an isolated antibody or antigen-binding fragment thereof that binds to human Sema3A. The isolated antibody or antigen-binding fragment according to the present disclosure i) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a dissociation constant (KD)≤50 nM, ≤20 nM, ≤10 nM, ≤1 nM, or ≤0.1 nM; ii) cross-reacts with mouse, cynomolgus, rat, pig and/or dog Sema3A, particularly wherein said isolated antibody or antigen-binding fragment thereof binds to mouse, cynomolgus, rat, pig and/or dog Sema3A with a dissociation constant (KD)≤50 nM, ≤20 nM, ≤10 nM, ≤1 nM, or ≤0.1 nM; iii) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a binding activity as measured by surface plasmon resonance (SPR) of ≥60%, ≥70%, ≥80%, or ≥90%; iv) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro mesangial cell migration assay with an EC50 of ≤10 nM, ≤5 nM, ≤2.5 nM, or ≤1 nM; v) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro growth cone collapse assay with an EC50 of ≤50 nM, ≤25 nM, ≤10 nM, or ≤5 nM; vi) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro HUVEC repulsion assay with an EC50 of ≤1 nM, or ≤0.3 nM, ≤0.1 nM, ≤0.07 nM, ≤0.06 nM and/or vii) exhibits an increased potency against cellular Sema3A, of the sequence of SEQ ID NO: 600, induced HUVEC repulsion.

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