公开(公告)号：US20180230176A1

公开(公告)日：2018-08-16

申请号：US15510268

申请日：2015-09-11

Applicant: BASF SE

Inventor： MICHAEL PUHL ,  Klaus DITRICH ,  Andreas KELLER ,  Pepa DIMITROVA ,  Melanie WEINGARTEN ,  Wolfgang SIEGEL

IPC: C07H15/26 ,  C07H3/06 ,  C07H1/00 ,  A23L33/10

CPC classification number: C07H15/26 ,  A23L33/10 ,  A23V2002/00 ,  C07H1/00 ,  C07H3/06

Abstract: The present invention relates to a method for preparing 2′-O-fucosyllactose, the 2′-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(═O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.