公开(公告)号：US20210002299A1

公开(公告)日：2021-01-07

申请号：US16982996

申请日：2019-03-20

申请人： Aurigene Discovery Technologies Limited

发明人： Dinesh CHIKKANNA ,  Sunil Kumar PANIGRAHI ,  Srinivasa Raju SAMMETA ,  Wohlfahrt GERD ,  Myllymaki MIKKO

IPC分类号： C07D498/08 ,  C07D401/14 ,  C07D401/06 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04 ,  A61P35/00

摘要： The present invention relates to the derivatives of compound of formula (I) and pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and use thereof as PRMT5 inhibitors. The compounds are useful as medicaments in the treatment of conditions where PRMT5 inhibition is desired, such as cancer, metabolic disorders, inflammation, autoimmune disease and hemoglobinopathies.

公开(公告)号：US20220324878A1

公开(公告)日：2022-10-13

申请号：US17843632

申请日：2022-06-17

申请人： Aurigene Discovery Technologies Limited

发明人： Dinesh CHIKKANNA ,  Sunil Kumar PANIGRAHI ,  Srinivasa Raju SAMMETA ,  Wohlfahrt GERD ,  Myllymaki MIKKO

IPC分类号： C07D498/08 ,  A61P35/00 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： The present invention relates to the derivatives of compound of formula (I) and pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and use thereof as PRMT5 inhibitors. The compounds are useful as medicaments in the treatment of conditions where PRMT5 inhibition is desired, such as cancer, metabolic disorders, inflammation, autoimmune disease and hemoglobinopathies.