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公开(公告)号：US20220125780A1
公开(公告)日：2022-04-28
申请号：US17570693
申请日：2022-01-07
IPC分类号： A61K31/4709 , C07D403/04 , C07D401/14 , C07D401/04 , C07D409/04 , C07D239/26 , C07D487/04 , C07D405/04 , A61K31/4985 , A61K31/501 , A61K31/506
摘要： The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
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公开(公告)号：US20210113551A9
公开(公告)日：2021-04-22
申请号：US16709692
申请日：2019-12-10
IPC分类号： A61K31/4709 , A61K31/506 , A61K31/501 , A61K31/4985 , C07D405/04 , C07D487/04 , C07D239/26 , C07D409/04 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
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