公开(公告)号：US20170319606A1

公开(公告)日：2017-11-09

申请号：US15528211

申请日：2015-11-20

申请人： Atlanthera

发明人： Maxim Egorov ,  Jean-Yves Goujon ,  Ronan Le Bot ,  Emmanuelle David

IPC分类号： A61K31/663 ,  C07C335/40 ,  C07F9/655 ,  C07H15/244

CPC分类号： A61K31/663 ,  A61K47/548 ,  C07C335/40 ,  C07F9/6552 ,  C07H15/244

摘要： The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.

公开(公告)号：US10238671B2

公开(公告)日：2019-03-26

申请号：US15528211

申请日：2015-11-20

申请人： Atlanthera

发明人： Maxim Egorov ,  Jean-Yves Goujon ,  Ronan Le Bot ,  Emmanuelle David

IPC分类号： A61K31/663 ,  C07F9/655 ,  C07C335/40 ,  C07H15/244 ,  A61K47/54

摘要： The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.