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公开(公告)号：US09453063B2
公开(公告)日：2016-09-27
申请号：US14195262
申请日：2014-03-03
发明人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
IPC分类号： A61K38/26 , C07K14/605 , C07K5/103 , C07K5/117 , C07K14/575 , C07K14/58 , A61K9/00 , A61K9/19 , A61K38/00
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
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2.发明申请PANCREATIC POLYPEPTIDE FAMILY MOTIFS, POLYPEPTIDES AND METHODS COMPRISING THE SAME 审中-公开胰蛋白多糖家族动物，聚合物及其包含的方法公开(公告)号：US20150231204A1
公开(公告)日：2015-08-20
申请号：US14539540
申请日：2014-11-12
发明人： Odile Esther LEVY , Carolyn M. Jodka , Soumitra S. Ghosh , David G. Parkes , Richard A. Pittner , Lawrence J. D'Souza , John S. Ahn , Kathryn S. Prickett , Jonathan David Roth , Sean H. Adams
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/00 , C07K14/475 , C07K14/575
摘要： The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.
摘要翻译： 本发明提供新型胰腺多肽家族（“PPF”）多肽及其使用方法。
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公开(公告)号：US20140249299A1
公开(公告)日：2014-09-04
申请号：US14195262
申请日：2014-03-03
发明人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
IPC分类号： C07K14/575 , C07K14/605
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关 条件。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的包括1型，2型和妊娠糖尿病的糖尿病。
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4.发明申请公开(公告)号：US20130281374A1
公开(公告)日：2013-10-24
申请号：US13868891
申请日：2013-04-23
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或 胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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公开(公告)号：US09133260B2
公开(公告)日：2015-09-15
申请号：US13849933
申请日：2013-03-25
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young
IPC分类号： A61K38/00 , A61P3/10 , C07K14/575 , C07K14/605
CPC分类号： C07K14/575 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或 胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。 这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。
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6.发明申请PANCREATIC POLYPEPTIDE FAMILY MOTIFS, POLYPEPTIDES AND METHODS COMPRISING THE SAME 有权胰蛋白多糖家族动物，聚合物及其包含的方法公开(公告)号：US20130303442A1
公开(公告)日：2013-11-14
申请号：US13858398
申请日：2013-04-08
发明人： Odile Esther LEVY , Carolyn M. Jodka , Soumitra S. Ghosh , David G. Parkes , Richard A. Pittner , Lawrence j. D'souza , John S. Ahn , Kathryn S. Prickett , Jonathan David Roth , Sean H. Adams
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K14/475
摘要： The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.
摘要翻译： 本发明提供新型胰腺多肽家族（“PPF”）多肽及其使用方法。
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公开(公告)号：US20130196913A1
公开(公告)日：2013-08-01
申请号：US13849933
申请日：2013-03-25
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
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8.发明授权Pancreatic polypeptide family motifs, polypeptides and methods comprising the same 有权胰多肽家族基序，多肽和包含其的方法公开(公告)号：US08906849B2
公开(公告)日：2014-12-09
申请号：US13858398
申请日：2013-04-08
发明人： Odile Esther Levy , Carolyn M. Jodka , Soumitra S. Ghosh , David G. Parkes , Richard A. Pittner , Lawrence J. D'Souza , John S. Ahn , Kathryn S. Prickett , Jonathan David Roth , Sean H. Adams
IPC分类号： A61K38/00 , A61P3/04 , C07K14/575 , C07K14/475
CPC分类号： C07K14/575 , A61K38/00 , C07K14/475
摘要： The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.
摘要翻译： 本发明提供了新型胰腺多肽家族（“PPF”）多肽及其使用方法。
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9.发明申请Compositions and Methods for the Control, Prevention and Treatment of Obesity and Eating Disorders 审中-公开控制，预防和治疗肥胖和饮食失调的组成和方法公开(公告)号：US20130225485A1
公开(公告)日：2013-08-29
申请号：US13631577
申请日：2012-09-28
IPC分类号： A61K38/22
摘要： Compositions and methods for preventing, treating or controlling conditions or disorders associated with obesity, diet and nutrition are provided. The methods provided generally involve the administration of an Amylin or an Amylin agonist to a subject in order to prevent, treat or control conditions or disorders associated with obesity, diet and nutrition.
摘要翻译： 提供了用于预防，治疗或控制与肥胖，饮食和营养相关的病症或障碍的组合物和方法。 所提供的方法通常包括向受试者施用胰岛淀粉样多肽和胰岛淀粉样多肽激动剂以预防，治疗或控制与肥胖，饮食和营养相关的病症或障碍。
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