公开(公告)号：US09815816B2

公开(公告)日：2017-11-14

申请号：US14805816

申请日：2015-07-22

Applicant: AstraZeneca AB

Inventor： Jorgen Blixt ,  Michael David Golden ,  Philip John Hogan ,  David Michael Glanville Martin ,  Francis Joseph Montgomery ,  Zakariya Patel ,  John David Pittam ,  George Joseph Sependa ,  Christopher John Squire ,  Nicholas Cartwright Alexander Wright

IPC: C07D401/12 ,  C07D211/16 ,  C07D239/94

CPC classification number: C07D401/12 ,  C07D211/16 ,  C07D239/94

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.