公开(公告)号：US20230219967A1

公开(公告)日：2023-07-13

申请号：US18174832

申请日：2023-02-27

Applicant: AstraZeneca AB

Inventor： Johan Olof BRODDEFALK ,  Hans Fredrik EMTENÂS ,  Kenneth Lars GRANBERG ,  Malin Anita LEMURELL ,  Daniel Tor PETTERSEN ,  Alleyn Thomas PLOWRIGHT ,  Lars Johan Andreas ULANDER

IPC: C07D487/04 ,  C07D413/12 ,  C07D498/04 ,  A61P11/00 ,  C07D231/40 ,  C07D231/44 ,  C07D417/12 ,  A61P9/00 ,  C07D231/50 ,  A61K31/4155 ,  A61P9/10 ,  A61K31/4985

CPC classification number: C07D487/04 ,  C07D413/12 ,  C07D498/04 ,  A61P11/00 ,  C07D231/40 ,  C07D231/44 ,  C07D417/12 ,  A61P9/00 ,  C07D231/50 ,  A61K31/4155 ,  A61P9/10 ,  A61K31/4985

Abstract: The present application relates to novel compounds of formula (I)




to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

公开(公告)号：US20200157113A1

公开(公告)日：2020-05-21

申请号：US16668743

申请日：2019-10-30

Applicant: ASTRAZENECA AB

Inventor： Johan Olof BRODDEFALK ,  Hans Fredrik EMTENÂS ,  Kenneth Lars GRANBERG ,  Malin Anita LEMURELL ,  Daniel Tor PETTERSEN ,  Alleyn Thomas PLOWRIGHT ,  Lars Johan Andreas ULANDER

IPC: C07D487/04 ,  C07D498/04 ,  C07D417/12 ,  C07D413/12 ,  C07D231/50 ,  C07D231/44 ,  C07D231/40

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

公开(公告)号：US20240317767A1

公开(公告)日：2024-09-26

申请号：US18670264

申请日：2024-05-21

Applicant: AstraZeneca AB

Inventor： Johan Olof BRODDEFALK ,  Hans Fredrik EMTENÂS ,  Kenneth Lars GRANBERG ,  Malin Anita LEMURELL ,  Daniel Tor PETTERSEN ,  Alleyn Thomas PLOWRIGHT ,  Lars Johan Andreas ULANDER

IPC: C07D487/04 ,  A61K31/4155 ,  A61K31/4985 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/4155 ,  A61K31/4985 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

Abstract: The present application relates to novel compounds of formula (I)




to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

公开(公告)号：US20230373983A1

公开(公告)日：2023-11-23

申请号：US18319560

申请日：2023-05-18

Applicant: AstraZeneca AB

Inventor： Daniel Tor PETTERSEN ,  Stéphanie Marcelle GUERET ,  Nidhal SELMI ,  Erik Lars MALMERBERG ,  Tord Bertil INGHARDT ,  Jan Åke LINDBERG ,  Jens Peter BRANDT ,  Jon Paul JANET ,  Björn Erik Anton HOLM

IPC: C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D413/04 ,  C07D487/04 ,  C07D471/04 ,  C07D409/06 ,  C07D271/06 ,  C07D498/10

CPC classification number: C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D413/04 ,  C07D487/04 ,  C07D471/04 ,  C07D409/06 ,  C07D271/06 ,  C07D498/10

Abstract: The specification relates to compounds of Formula (I):




and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as liver disease.

公开(公告)号：US20250011311A1

公开(公告)日：2025-01-09

申请号：US18884381

申请日：2024-09-13

Applicant: AstraZeneca AB

Inventor： Daniel Tor PETTERSEN ,  Stéphanie Marcelle GUERET ,  Nidhal SELMI ,  Erik Lars MALMERBERG ,  Tord Bertil INGHARDT ,  Jan Åke LINDBERG ,  Jens Peter BRANDT ,  Jon Paul JANET ,  Björn Erik Anton HOLM

IPC: C07D413/06 ,  C07D271/06 ,  C07D409/06 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/10

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as liver disease.

公开(公告)号：US20190084991A1

公开(公告)日：2019-03-21

申请号：US16196217

申请日：2018-11-20

Applicant: ASTRAZENECA AB

Inventor： Johan Olof BRODDEFALK ,  Hans Fredrik EMTENÂS ,  Kenneth Lars GRANBERG ,  Malin Anita LEMURELL ,  Daniel Tor PETTERSEN ,  Alleyn Thomas PLOWRIGHT ,  Lars Johan Andreas ULANDER

IPC: C07D487/04 ,  C07D231/44 ,  C07D231/40 ,  C07D498/04 ,  C07D231/50 ,  C07D417/12 ,  C07D413/12

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

公开(公告)号：US20180237439A1

公开(公告)日：2018-08-23

申请号：US15571291

申请日：2016-05-03

Applicant: ASTRAZENECA AB

Inventor： Johan Olof BRODDEFALK ,  Hans Fredrik EMTENÄS ,  Kenneth Lars GRANBERG ,  Malin Anita LEMURELL ,  Daniel Tor PETTERSEN ,  Alleyn Thomas PLOWRIGHT ,  Lars Johan Andreas ULANDER

IPC: C07D487/04 ,  C07D498/04 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D487/04 ,  C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.