公开(公告)号：US20170320906A1

公开(公告)日：2017-11-09

申请号：US15528475

申请日：2015-11-26

申请人： Aston University

发明人： Daniel Lee Rathbone ,  Tony Worthington ,  Sahar Al-Malaika ,  Matthew Justin Hird ,  Alexandria Rose Quayle

IPC分类号： C07J43/00 ,  C07J41/00 ,  C07J9/00 ,  A61K45/06 ,  A61K31/58 ,  C08F293/00 ,  A61K31/575

摘要： The invention relates to compounds, compositions and polymers comprising a first component adapted to promote germination of Clostridium difficile (C.diff) and a second component which acts as an antimicrobial agent. Said compounds, compositions and polymers are useful for destroying C.diff where conventional antimicrobial agents are unsuccessful. The compositions can be formulated as coating or materials which actively destroy C.diff which come into contact with it. The germination promotion is induced by bile salts. The invention also relates to the use of such materials as a treatment for C.diff associated diseases and toxic megacolon.

公开(公告)号：US10519192B2

公开(公告)日：2019-12-31

申请号：US15528475

申请日：2015-11-26

申请人： Aston University

发明人： Daniel Lee Rathbone ,  Tony Worthington ,  Sahar Al-Malaika ,  Matthew Justin Hird ,  Alexandria Rose Quayle

IPC分类号： A61K31/575 ,  A61K31/58 ,  A61K45/06 ,  A61K47/54 ,  C07J43/00 ,  C07J9/00 ,  C07J41/00 ,  C08F293/00

摘要： The invention relates to compounds, compositions and polymers comprising a first component adapted to promote germination of Clostridium difficile (C.diff) and a second component which acts as an antimicrobial agent. Said compounds, compositions and polymers are useful for destroying C.diff where conventional antimicrobial agents are unsuccessful. The compositions can be formulated as coating or materials which actively destroy C.diff which come into contact with it. The germination promotion is induced by bile salts. The invention also relates to the use of such materials as a treatment for C.diff associated diseases and toxic megacolon.