公开(公告)号：US20230183326A1

公开(公告)日：2023-06-15

申请号：US17812543

申请日：2022-07-14

Applicant: Asana BioSciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: C07K16/18 ,  A61K47/59 ,  A61K47/68

CPC classification number: C07K16/18 ,  A61K47/59 ,  A61K47/6843 ,  A61K47/6883

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

公开(公告)号：US20150125474A1

公开(公告)日：2015-05-07

申请号：US14512275

申请日：2014-10-10

Applicant: Asana Biosciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: A61K47/48 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K47/59 ,  A61K47/6843 ,  A61K47/6883

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

公开(公告)号：US20190241649A1

公开(公告)日：2019-08-08

申请号：US16382735

申请日：2019-04-12

Applicant: Asana BioSciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: C07K16/18 ,  A61K47/68 ,  A61K47/59

CPC classification number: C07K16/18 ,  A61K47/59 ,  A61K47/6843 ,  A61K47/6883

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

公开(公告)号：US11434278B2

公开(公告)日：2022-09-06

申请号：US16382735

申请日：2019-04-12

Applicant: Asana BioSciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: C07K16/18 ,  A61K47/59 ,  A61K47/68

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

公开(公告)号：US10316080B2

公开(公告)日：2019-06-11

申请号：US14512275

申请日：2014-10-10

Applicant: Asana Biosciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: A61K47/68 ,  A61K47/60 ,  C07K16/18 ,  A61K47/59

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

公开(公告)号：US20240082417A1

公开(公告)日：2024-03-14

申请号：US17812498

申请日：2022-07-14

Applicant: Asana BioSciences, LLC

Inventor： Roger A. Smith ,  Nitin K. Damle ,  Aleksandr V. Yurkovetskiy ,  Mao Yin ,  Timothy B. Lowinger ,  Joshua D. Thomas ,  Cheri A. Stevenson ,  Venu R. Gurijala

IPC: A61K47/68 ,  A61K47/60 ,  A61P35/00 ,  C07K16/30

CPC classification number: A61K47/6851 ,  A61K47/60 ,  A61K47/6803 ,  A61P35/00 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/92

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.