专利检索 ap:("Arvinas Operations, Inc.") AND inv:"Katharine Victoria BOULTON" 第 1 页

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发明申请
CRYSTALLINE AND AMORPHOUS FORMS OF A COMPOUND FOR THE TARGETED DEGRADATION OF ESTROGEN RECEPTOR 有权

公开(公告)号：US20220081416A1

公开(公告)日：2022-03-17

申请号：US17472847

申请日：2021-09-13

申请人： Arvinas Operations, Inc.

发明人： Katharine Victoria BOULTON , Chungpin Herman CHEN , Royal J. HASKELL, III , Hayley REECE

IPC分类号： C07D401/14

摘要： The present disclosure relates to polymorphic forms of (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, methods of making these polymorphic forms, and compositions comprising these polymorphic forms. These polymorphic forms are useful in the treatment of various diseases, including, for example, breast cancer.