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公开(公告)号：US20240101553A1
公开(公告)日：2024-03-28
申请号：US18230580
申请日：2023-08-04
Applicant: MIRATI THERAPEUTICS, INC. , ARRAY BIOPHARMA INC.
Inventor： Matthew Arnold MARX , James Gail CHRISTENSEN , Christopher Ronald SMITH , James F. BLAKE , Laurence E. BURGESS , Mark Joseph CHICARELLI , Adam COOK , Jay Bradford FELL , John P. FISCHER , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Pavel SAVECHENKOV , Tony P. TANG , Guy P.A. VIGERS
IPC: C07D471/04 , A61P35/00 , C07D491/08
CPC classification number: C07D471/04 , A61P35/00 , C07D491/08
Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20210269432A1
公开(公告)日：2021-09-02
申请号：US16099398
申请日：2017-05-17
Applicant: MIRATI THERAPEUTICS, INC. , ARRAY BIOPHARMA INC.
Inventor： John P. FISCHER , Jay Bradford FELL , James F. BLAKE , Ronald Jay HINKLIN , Macedonio J. MEJIA , Erik James HICKEN , Mark Joseph CHICARELLI , John J. GAUDINO , Guy P.A. VIGERS , Laurence E. BURGESS , Matthew Arnold MARX , James Gail CHRISTENSEN , Matthew Randolf LEE , Pavel SAVECHENKOV , Henry J. ZECCA , Tony P. TANG
IPC: C07D471/04 , C07D519/00 , A61P35/00
Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20230373999A1
公开(公告)日：2023-11-23
申请号：US18048834
申请日：2022-10-21
Applicant: MIRATI THERAPEUTICS, INC. , ARRAY BIOPHARMA INC.
Inventor： Matthew Arnold MARX , James Gail CHRISTENSEN , Christopher Ronald SMITH , James F. BLAKE , Laurence E. BURGESS , Mark Joseph CHICARELLI , Adam COOK , Jay Bradford FELL , John P. FISCHER , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Pavel SAVECHENKOV , Tony P. TANG , Guy P.A. VIGERS
IPC: C07D471/04 , A61P35/00 , C07D491/08
CPC classification number: C07D471/04 , A61P35/00 , C07D491/08
Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20210380582A1
公开(公告)日：2021-12-09
申请号：US17285997
申请日：2019-10-17
Applicant: Array BioPharma Inc.
Inventor： James Francis BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam Wade COOK , Mohamed S. A. ELSAYED , Jay Bradford FELL , John Peter FISCHER , Ronald Jay HINKLIN , Oren Teague MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina Elizabeth WONG
IPC: C07D471/04 , C07D519/00
Abstract: Compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed
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Patent Agency Ranking
公开(公告)号：US20200317665A1
公开(公告)日：2020-10-08
申请号：US16835702
申请日：2020-03-31
Applicant: Array BioPharma Inc.
Inventor： James F. BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam W. COOK , Mohamed S. A. ELSAYED , Jay Bradford FELL , John P. FISCHER , Ronald Jay HINKLIN , Yutong JIANG , Oren T. MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina E. WONG
IPC: C07D471/04 , C07D401/14 , C07D513/10 , C07D471/10 , A61P35/00
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20130065901A1
公开(公告)日：2013-03-14
申请号：US13669083
申请日：2012-11-05
Applicant: Array BioPharma Inc.
Inventor： Thomas Daniel AICHER , Steven Armen BOYD , Mark Joseph CHICARELLI , Kevin Ronald CONDROSKI , Ronald Jay HINKLIN , Ajay SINGH
IPC: A61K31/4439 , C07D417/14 , A61K31/444 , A61K31/4545 , C07D471/04 , A61K31/506 , C07D495/04 , C07D498/04 , C07D487/04 , A61K31/519 , A61K31/517 , A61K31/497 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61P3/10 , C07D417/12
CPC classification number: C07D417/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
Abstract translation: 提供了可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病的化合物。 还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。
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公开(公告)号：US20250066357A1
公开(公告)日：2025-02-27
申请号：US18946138
申请日：2024-11-13
Applicant: Array BioPharma Inc.
Inventor： James Francis BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam Wade COOK , Mohamed S.A. ELSAYED , Jay Bradford FELL , John Peter FISCHER , Ronald Jay HINKLIN , Oren Teague MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina Elizabeth WONG
IPC: C07D471/04 , C07D519/00
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed
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公开(公告)号：US20240124453A1
公开(公告)日：2024-04-18
申请号：US18512473
申请日：2023-11-17
Applicant: Array BioPharma Inc.
Inventor： James Francis BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam Wade COOK , Mohamed S. A. ELSAYED , Jay Bradford FELL , John P. FISCHER , Ronald Jay HINKLIN , Yutong JIANG , Oren Teague MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina Elizabeth WONG
IPC: C07D471/04 , A61P35/00 , C07D401/14 , C07D471/10 , C07D513/10
CPC classification number: C07D471/04 , A61P35/00 , C07D401/14 , C07D471/10 , C07D513/10 , A61K45/06
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20220251083A1
公开(公告)日：2022-08-11
申请号：US17720070
申请日：2022-04-13
Applicant: Array BioPharma Inc.
Inventor： James Francis BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam Wade COOK , Mohamed S. A. ELSAYED , Jay Bradford FELL , John P. FISCHER , Ronald Jay HINKLIN , Yutong JIANG , Oren Teague MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina Elizabeth WONG
IPC: C07D471/04 , A61P35/00 , C07D401/14 , C07D471/10 , C07D513/10
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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