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公开(公告)号：US09655904B2
公开(公告)日：2017-05-23
申请号：US14817291
申请日：2015-08-04
发明人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong-Woon Yang
IPC分类号： A01N43/00 , A61K31/55 , C07D223/14 , C07D401/12 , C07D401/14 , C07D403/10 , C07D223/16 , C07D401/04 , C07D405/04 , C07D405/10
CPC分类号： A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-versus-host disease.
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公开(公告)号：US09556139B2
公开(公告)日：2017-01-31
申请号：US14702947
申请日：2015-05-04
申请人： Array BioPharma Inc.
发明人： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff , Ganghyeok Kim
IPC分类号： A61K31/352 , C07D311/58 , C07D405/12 , C07D407/12
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： Provided herein are compounds of Formula I: in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, which are DP2 receptor modulators useful in the treatment of immunologic diseases.
摘要翻译： 式（Ⅳ，Ⅵ）化合物：其中A1，A2，P2，P3，R7a，R7b，R8，R9，R10和Z2具有说明书中给出的含义，是可用于制备DP2受体调节剂的化合物 免疫疾病的治疗。
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公开(公告)号：US09126940B2
公开(公告)日：2015-09-08
申请号：US14180939
申请日：2014-02-14
发明人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong-Woon Yang
IPC分类号： A01N43/00 , A61K31/55 , C07D223/16 , C07D223/14 , C07D401/12 , C07D401/14 , C07D403/10 , C07D401/04 , C07D405/04 , C07D405/10
CPC分类号： A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US11267812B2
公开(公告)日：2022-03-08
申请号：US16099398
申请日：2017-05-17
发明人： John P. Fischer , Jay Bradford Fell , James F. Blake , Ronald Jay Hinklin , Macedonio J. Mejia , Erik James Hicken , Mark Joseph Chicarelli , John J. Gaudino , Guy P. A. Vigers , Laurence E. Burgess , Matthew Arnold Marx , James Gail Christensen , Matthew Randolph Lee , Pavel Savechenkov , Henry J. Zecca , Tony P. Tang
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20190062330A1
公开(公告)日：2019-02-28
申请号：US16173726
申请日：2018-10-29
发明人： James F. Blake , Laurence E. Burgess , Mark Joseph Chicarelli , James Gail Christensen , Jay Bradford Fell , John P. Fischer , John J. Gaudino , Erik James Hicken , Ronald Jay Hinklin , Matthew Randolf Lee , Matthew Arnold Marx , Macedonio J. Mejia , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Henry J. Zecca
IPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US08716498B2
公开(公告)日：2014-05-06
申请号：US14013898
申请日：2013-08-29
申请人： Array BioPharma Inc.
发明人： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff , Ganghyeok Kim
IPC分类号： C07D311/58
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： A compound having the formula: is useful in the preparation of compounds of Formula I.
摘要翻译： 具有下式的化合物可用于制备式I化合物。
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公开(公告)号：US20140005418A1
公开(公告)日：2014-01-02
申请号：US14013898
申请日：2013-08-29
申请人： ARRAY BIOPHARMA INC.
发明人： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff , Ganghyeok Kim
IPC分类号： C07D311/58
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： A compound having the formula: is useful in the preparation of compounds of Formula I.
摘要翻译： 具有下式的化合物可用于制备式I化合物。
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![4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors](/abs-image/US/2021/06/08/US11028093B2/abs.jpg.150x150.jpg)
公开(公告)号：US11028093B2
公开(公告)日：2021-06-08
申请号：US16890663
申请日：2020-06-02
发明人： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC分类号： A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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![4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS](/abs-image/US/2017/12/21/US20170362240A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170362240A1
公开(公告)日：2017-12-21
申请号：US15532937
申请日：2015-12-04
发明人： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：US20160129010A1
公开(公告)日：2016-05-12
申请号：US14817291
申请日：2015-08-04
发明人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong-Woon Yang
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-versus-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎症性疾病，移植排斥反应和移植物抗宿主病。
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