公开(公告)号：US20240190843A1

公开(公告)日：2024-06-13

申请号：US18553214

申请日：2022-03-30

Applicant: Array BioPharma Inc.

Inventor： Katie Keaton BROWN ,  Aaron Keith GOODWIN

IPC: C07D401/14 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/53 ,  A61K39/00 ,  C07K16/28

CPC classification number: C07D401/14 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/53 ,  C07K16/2863 ,  A61K2039/505

Abstract: This Invention relates to a hemihydrate crystalline form of (S)-1′-(6-((2-amino-3-chloropyridin-4-yl)thio)-1,2,4-triazin-3-yl)-1,3-dihydrospiro[indene-2,4′-piperidin]-1-amine free base (Form 1). The invention also relates to pharmaceutical compositions comprising this crystalline form, and to methods of using the crystalline form and such compositions for the treatment of abnormal cell growth, such as cancer, in a mammal.